Summary
Organic pyrophosphates such as UppA and NAD are formed when a solution containing a nucleotide, a nucleoside 5′-polyphosphate, Mg2+ and imidazole are allowed to dry out. We suggest that this synthesis may have occured concurrently with oligonucleotide formation.
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Abbreviations
- Im:
-
Imidazole
- CDI:
-
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
- EDTA:
-
ethylenediaminetetraacetic acid
- A:
-
adenosine
- U:
-
uridine
- pnA:
-
adenosine 5′-poly-phosphate containing n phosphate residues
- pU:
-
uridine 5′-phosphate
- AppA:
-
P1,P2-diadenosine 5′-pyrophosphate
- UppA:
-
P1-(uridine 5′)-P2-(adenosine 5′)-pyrophosphate
- ImpA:
-
adenosine 5′-phosphorimidazolide
- NMN:
-
nicotinamide mononucleotide
- NAD:
-
nicotinamide-adenine dinucleotide
References
Lehninger, A.L. (1975). In: Biochemistry, 2nd ed. Chapter37, 1040, New York: Worth Publishers, Inc.
Lohrmann, R. (1975). J. Mol. Evol.6, 237
Lohrmann, R. (1976). J. Mol. Evol.8, 197
Lohrmann, R. (1977). J. Mol. Evol.10, 137
Lohrmann, R., Orgel, L.E. (1973). Nature244, 418
Lohrmann, R., Ranganathan, R., Sawai, H., Orgel, L.E. (1975) J. Mol. Evol.5, 57
Lowenstein, J.M. (1958). Biochem. J.70, 222
Lowenstein, J.M. (1960). Biochem. J.75, 209
Orgel, L.E. (1968). J. Mol. Biol.38, 381
Orgel, L.E., Lohrmann, R. (1974). Accounts of Chem. Res.7, 368
Orgel, L.E., Sulston, J.E. (1971). In: Prebiotic and Biochemical Evolution, A.P. Kimball and J. Orô eds., pp. 89–94, Amsterdam-London: North-Holland Publ. Comp.
Sawai, H., Lohrmann, R., Orgel, L.E. (1975) J. Mol. Evol.6, 165
Sawai, H., Orgel, L.E. (1975). J. Mol. Evol.6, 185
Smith, M., Khorana, H.G. (1958). J. Am. Chem. Soc.80, 1141
White, H.B. (1976). J. Mol. Evol.7, 101
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Lohrmann, R., Orgel, L.E. Formation of P1, P2-dinucleoside 5′-pyrophosphates under potentially prebiological conditions. J Mol Evol 11, 17–23 (1978). https://doi.org/10.1007/BF01768021
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DOI: https://doi.org/10.1007/BF01768021