Journal of Bone and Mineral Metabolism

, Volume 14, Issue 4, pp 187–192 | Cite as

Mechanism of osteoclast-mediated bone resorption

  • H. Kalervo Väänänen
  • Jari Salo
  • Petri Lehenkari
Review Articles

Key words

osteoclast bone resorption 

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References

  1. 1.
    Suda TN, Takahashi N, Martin TJ (1995) Modulation of osteoclast differentation: update 1995. Endocr Rev 4:266–270Google Scholar
  2. 2.
    Lakkakorpi PT, Lehenkari PP, Rautiala TJ, Väänänen HK (1996) Resorbing osteoclasts are insensitive to changes in extracellular calcium. Microsc Res Techn 33:171–181Google Scholar
  3. 3.
    Lakkakorpi PT, Väänänen HK (1991) Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro. J Bone Miner Res 6:817–826PubMedGoogle Scholar
  4. 4.
    Lakkakorpi P, Tuukkanen J, Hentunen T, Järvelin K, Väänänen HK (1989) Organization of osteoclast microfilaments during the attachement to bone surface in vitro. J Bone Miner Res 4:817–825PubMedGoogle Scholar
  5. 5.
    Salo J, Metsikkö K, Palokangas H, Lehenkari P, Väänänen HK (1996) Bone-resorbing osteoclasts reveal a dynamic division of basal membrane into two different domains. J Cell Sci 109:301–307PubMedGoogle Scholar
  6. 6.
    Sugiyama T, Kusuhara S (1994) The kinetics of actin filaments in osteoclasts on chicken medullary bone during the egg-laying cycle. Bone 15:351–353PubMedGoogle Scholar
  7. 7.
    Zambonin-Zallone A, Teti A, Carano A, Marchisio PC (1988) The distribution of podosomes in osteoclasts cultured on bone laminae: effect of retinol. J Bone Miner Res 3:517–523PubMedGoogle Scholar
  8. 8.
    Väänänen HK, Horton M (1995) The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure. J Cell Sci 108:2729–2732PubMedGoogle Scholar
  9. 9.
    Laitala-Leinonen T, Howell ML, Dean GE, Väänänen HK (1996) Resorption-cycle dependent polarization of mRNAs for different subunits of V-ATPase in bone resorbing osteoclasts. Mol Biol Cell 7:129–142PubMedGoogle Scholar
  10. 10.
    Salo J, Metsikkö K, Väänänen HK (1994) Novel transcytotic route for degraded bone matrix material in osteoclasts. Mol Biol Cell 5 [Suppl]:431Google Scholar
  11. 11.
    Fallon MD (1984) Bone resorbing fluid from osteoclasts is acidic: an in vitro micropuncture study. In: Conn CV, Fujita JR, Potts JR, Talmadge, RV (eds) Endocrine control of bone and calcium metabolism. Elsevier/North Holland, Amsterdam, p 144–146Google Scholar
  12. 12.
    Blair HC, Teitelbaum SL, Ghiselli R, Gluck S (1989) Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 245:855–857PubMedGoogle Scholar
  13. 13.
    Väänänen HK, Karhukorpi EK, Sundquist K, Wallmark B, Roininen I, Hentunen T, Tuukkanen J, Lakkakorpi P (1990) Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts. J Cell Biol 111:1305–1311PubMedGoogle Scholar
  14. 14.
    Bekker PJ, Gay CV (1990) Biochemical characterization of an electrogenic vacuolar proton pump in purified chicken osteoclast plasma membrane vesicles. J Bone Miner Res 5:569–579PubMedGoogle Scholar
  15. 15.
    Sundquist K, Lakkakorpi P, Wallmark B, Väänänen K (1990) Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption. Biochem Biophys Res Commun 168:309–313PubMedGoogle Scholar
  16. 16.
    Mattsson JP, Väänänen K, Wallmark B, Lorentzon P (1991) Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases. Biochim Biophys Acta 1065:261–268PubMedGoogle Scholar
  17. 17.
    Laitala T, Väänänen HK (1994) Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase. J Clin Invest 93:2311–2318PubMedGoogle Scholar
  18. 18.
    Sundqvist K, Marks S (1995) Bafilomycin A1 inhibits bone resorption and tooth eruption in vivo. J Bone Miner Res 9:1575–1582Google Scholar
  19. 19.
    Yamamoto T, Kurihara N, Yamaoka K, Ozono K, Okada M, Yamamoto K, Matsumoto S, Michigami T, Ono J, Okada S (1993) Bone marrow-derived osteoclast-like cells from a patient with craniometaphyseal dysplasia lack expression of osteoclast-reactive vacuolar proton pump. J Clin Invest 91:362–367PubMedGoogle Scholar
  20. 20.
    Palokangas H, Metsikkö K, Väänänen HK (1994) Active vacuolar H+-ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells. J Biol Chem 269:17577–17585PubMedGoogle Scholar
  21. 21.
    Hernando N, Bartkiewicz M, Collinosdoby P, Osdoby P, Baron R (1995) Alternative splicing generates a second isoform of the catalytic A subunit of the vacuolar H+-ATPase. Proc Natl Acad Sci USA 92:6087–6091PubMedGoogle Scholar
  22. 22.
    van Hille B, Richener H, Schmid P, Puettner I, Green JR, Bilbe G (1994) Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms. Biochem J 303:191–198PubMedGoogle Scholar
  23. 23.
    Minkin C, Jennings JM (1972) Carbonic anhydrase and bone remodeling: Sulfonamide inhibition of bone resorption in organ culture. Science 176:1031–1033PubMedGoogle Scholar
  24. 24.
    Blair HC, Schlesinger PH (1990) Purification of a stilbene sensitive chloride channel and reconstitution of chloride conductivity into phospholipid vesicles. Biochem Biophys Res Commun 171:920–925PubMedGoogle Scholar
  25. 25.
    Hall TJ, Schaeublin M, Chambers TJ (1992) Na+/H(+)-antiporter activity is essential for the induction, but not the maintenance of osteoclastic bone resorption and cytoplasmic spreading. Biochem Biophys Res Commun 188:1097–1103PubMedGoogle Scholar
  26. 26.
    Nordstrom T, Rotstein OD, Romanek R, Asotra S, Heersche JN, Manolson MF, Brisseau GF, Grinstein S (1995) Regulation of cytoplasmic pH in osteoclasts. Contribution of proton pumps and a proton-selective conductance. J Biol Chem 270:2203–2212PubMedGoogle Scholar
  27. 27.
    Chambers TJ, Darby JA, Fuller K (1985) Mammalian collagenase predisposes bone surfaces to osteoclastic resorption. Cell Tiss Res 241:671–675Google Scholar
  28. 28.
    Delaisse JM, Eeckhout Y, Neff L, François-Gillet C, Henriet P, Su Y, Vaes G, Baron R (1993) (Pro)collagenase (matrix metalloproteinase-1) is present in redent osteoclasts and in the underlying bone-resorbing compartment. J Cell Sci 106:1071–1082PubMedGoogle Scholar
  29. 29.
    Okamura T, Shimokawa H, Takagi Y, Ono H, Sasaki S, (1993) Detection of collagenase mRNA in odontoclasts of bovine root-resorbing tissue by in situ hybridization. Calcif Tissue Int 52:325–330PubMedGoogle Scholar
  30. 30.
    Fuller K, Chambers TJ (1995) Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells but not osteoclasts. J Cell Sci 108:2221–2230PubMedGoogle Scholar
  31. 31.
    Okada Y, Naka K, Kawamura K, Matsumoto T (1995) Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption. Lab Invest 72:311–316PubMedGoogle Scholar
  32. 32.
    Reponen P, Sahlberg C, Munaut C, Thesleff I, Tryggvason K (1994) High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J Cell Biol 124:1091–1102PubMedGoogle Scholar
  33. 33.
    Goto T, Kiyoshima T, Moroi R, Tsukuba T, Nishimura Y, Himeno M, Yamamoto K, Tanaka T (1994) Localization of cathepsins B, D, and L in the rat osteoclast by immuno-light and -electron microscopy. Histochemistry 101:33–40PubMedGoogle Scholar
  34. 34.
    Goto T, Tsukuba T, Kiyoshima T, Nishimura Y, Kato K, Yamamoto K, Tanaka T (1993) Immunohistochemical localization of cathepsins B, D and L in the rat osteoclasts. Histochemistry 99:411–414PubMedGoogle Scholar
  35. 35.
    Hill PA, Buttle DJ, Jones SJ, Boyde A, Murata M, Reynolds JJ, Meikle MC (1994) Inhibition of bone resorption by selective inactivators of cysteine proteinases. J Cell Biochem 56:118–130PubMedGoogle Scholar
  36. 36.
    Blair HC, Teitelbaum SL, Grosso LE, Lacey DL, Tan HL, McCourt DW, Jeffrey JJ (1993) Extracellular-matrix degradation at acid pH. Avian osteoclast acid collagenase isolation and characterization. Biochem J 290:873–884PubMedGoogle Scholar
  37. 37.
    Bromme D, Okamoto K (1995) Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution. Biol Chem Hoppe Seyler 376:379–384PubMedGoogle Scholar
  38. 38.
    Shi GP, Chapman HA, Bhairi SM, DeLeeuw C, Reddy VY, Weiss SJ (1995) Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. FEBS Lett 357:129–134PubMedGoogle Scholar
  39. 39.
    Ek-Rylander B, Florest M, Wendel M, Heinegård D, Andersson G (1994) Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. 21:14853–14856Google Scholar
  40. 40.
    Key LL, Wolf WC, Gundberg CM, Ries WL (1994) Superoxide and bone resorption. Bone 15:431–436PubMedGoogle Scholar
  41. 41.
    Silverton S (1994) Osteoclast radicals. J Cell Biochem 56:367–373PubMedGoogle Scholar
  42. 42.
    Hayman AR, Foster D, Colledge WH, Evans MJ, Cox TM (1995) Tartrate resistant acid phosphatase is essential for normal bone development in the mouse. J Bone Miner Res 10 [Suppl I]:158Google Scholar
  43. 43.
    Lindunger A, MacKay CA, Ek-Rylander B, Andersson G, Marks Jr SC (1990) Histochemistry and biochemistry of tartrate-resistant acid phosphatase (TRAP) and tartrate-resistant acid adenosine triphosphatase (TrATPase) in bone, bone marrow and spleen: implications for osteoclast ontogeny. Bone Miner 109–119Google Scholar
  44. 44.
    Reinholt FP, Widholm SM, Ek-Rylander B, Andersson G (1990) Ultrastructural localization of a tartrate-resistant acid ATPase in bone. J Bone Miner Res 5:1055–1061PubMedGoogle Scholar
  45. 45.
    Clark SA, Ambrose WW, Anderson TR, Terrell RS, Toverud SU (1989) Ultrastructural localization of tartrate-resistant, purple acid phosphatase in rat osteoclasts by histochemistry and immunocytochemistry. J Bone Miner Res 4:399–405PubMedGoogle Scholar
  46. 46.
    Boyce BF, Yoneda T, Lowe C, Soriano P, Mundy GR (1992) Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest 90: 1622–1627PubMedGoogle Scholar
  47. 47.
    Kanehisa J, Heersche JN (1988) Osteoclastic bone resorption: in vitro analysis of the rate of resorption and migration of individual osteoclasts. Bone 9:73–79PubMedGoogle Scholar
  48. 48.
    Hughes DE, Wright KR, Uy HL, Sakaki A, Yoneda T, Mundy GD, Boyce B (1995) Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478–1487PubMedGoogle Scholar
  49. 49.
    Solari F, Domenget C, Gire V, Woods C, Lazarides E, Rousset B, Jurdic P, (1995) Multinucleated cells can continuously generate mononucleated cells in the absence of mitosis: A study of cells of the avian osteoclast lineage. J Cell Sci 108:3233–3241PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • H. Kalervo Väänänen
    • 1
  • Jari Salo
    • 1
  • Petri Lehenkari
    • 1
  1. 1.Department of Anatomy and Biocenter OuluUniversity of OuluOuluFinland

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