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Increase in radiosensitivity of lung micrometastases by hyperbaric oxygen

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Abstract

Four-day-old artificial pulmonary micrometastases of two murine fibrosarcomas, designated FSA and NFSA, showed increased sensitivity to ionizing radiation by a factor of 1·13 when animals were exposed to hyperbaric oxygen breathing before and during irradiation, implying the presence of hypoxia in the micrometastases. At the time of irradiation the diameter of FSA and NFSA metastases was smaller than 200 and 100μm, respectively, which, on the basis of oxygen diffusion, could not be responsible for hypoxia. It is assumed that hypoxia of micrometastases is passive, reflecting the radiobiological hypoxia of lung tissue that could exist under normal breathing conditions.

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References

  1. Ando, K., Hunter, N., andPeters, L. J., 1979, Immunologically nonspecific enhancement of artificial lung metastases in tumor-bearing mice.Cancer Immunology and Immunotherapy,6, 151–156.

    Google Scholar 

  2. Hall, E. J., 1978,Radiobiology for the Radiotherapist, second edition (Philadelphia: Harper & Row).

    Google Scholar 

  3. Mason, K. A., andWithers, H. R., 1977, RBE of neutrons generated by 50meV deuterons on beryllium for control of artificial pulmonary metastases of a mouse fibrosarcoma.British Journal of Radiology,50, 652–657.

    Google Scholar 

  4. Meyn, R. E., andJenkins, W. T., 1983, Variation in normal and tumor tissue sensitivity of mice to ionizing radiation-induced DNA strand breaksin vivo.Cancer Research,43, 5668–5673.

    Google Scholar 

  5. Milas, L., Ito, H., andHunter, N., 1983, Effect of tumor size onS-2-(3-aminopropylamino)ethylphosphorothioic acid and misonidazole alteration of tumor response to cyclophosphamide.Cancer Research,43, 3050–3056.

    Google Scholar 

  6. Milas, L., Hunter, N., Masson, K., andWithers, H. R., 1974, Immunological resistance to pulmonary metastases in C3Hf/Bu mice bearing syngeneic fibrosarcoma of different sizes.Cancer Research,34, 61–71.

    Google Scholar 

  7. Milas, L., Kogelnik, H. D., Basic, I., Mason, K., Hunter, N., andWithers, H. R., 1975, Combination ofC. parvum and specific immunization against artificial pulmonary metastases in mice.International Journal of Cancer,16, 738–746.

    Google Scholar 

  8. Parkins, C., Fowler, J. F., andDenekamp, J., 1983, Low radioprotection by thiol in lung: the role of local tissue oxygenation.European Journal of Cancer Clinical Oncology,19, 1169–1172.

    Google Scholar 

  9. Pike, M. C., andAlper, T., 1964, A method for determining dose-modification factors.British Journal of Radiology,37, 458–462.

    Google Scholar 

  10. Shipley, W. U., Stanley, J. A., andSteel, G. G., 1976, Enhanced tumor cell radiosensitivity in artificial pulmonary metastases of the Lewis lung carcinoma.International Journal of Radiation Oncology, Biology and Physics,1, 261–265.

    Google Scholar 

  11. Steel, G. G., andAdams, K., 1975, Stem-cell survival and tumor control in the Lewis lung carcinoma.Cancer Research,35, 1530–1535.

    Google Scholar 

  12. Suit, H. D., andMaeda, M., 1967, Hyperbaric oxygen and radiobiology of a C3H mouse mammary carcinoma.Journal of the National Cancer Institute,39, 639–652.

    Google Scholar 

  13. Suit, H. D., andSuchato, C., 1967, Hyperbaric oxygen and radiotherapy of a fibrosarcoma and of a squamous-cell carcinoma of C3H mice.Radiology,87, 713–719.

    Google Scholar 

  14. Sutherland, R. M., andDurand, R. E., 1976, Radiation response of multicell spheroids—anin vitro tumor model.Current Topics in Radiation Research,11, 87–139.

    Google Scholar 

  15. Thomlinson, R. H., andGray, L. H., 1955, The histological structure of some human lung cancers and the possible implications for radiotherapy.British Journal of Cancer,9, 539–549.

    Google Scholar 

  16. Travis, E. L., andDe Luca, A. M., 1984, The effect of breathing 100% oxygen on lung response to radiation in mice.Radiotherapy and Oncology, (in the press).

  17. Withers, H. R., andPeters, L. J., 1980, Biological Aspects of Radiation Therapy.Textbook of Radiotherapy, third edition, edited by G. H. Fletcher (Philadelphia: Lea & Febiger), pp. 103–180.

    Google Scholar 

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Author notes

  1. Hisao Ito

    Present address: Department of Radiobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Authors and Affiliations

  1. Department of Experimental Radiotherapy, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 77030, Houston, Texas, USA

    Luka Milas, Nancy M. Hunter, Hisao Ito, William A. Brock & Lester J. Peters

  2. Division of Radiotherapy, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 77030, Houston, Texas, USA

    Lester J. Peters

Authors
  1. Luka Milas
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  2. Nancy M. Hunter
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  3. Hisao Ito
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  4. William A. Brock
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  5. Lester J. Peters
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Milas, L., Hunter, N.M., Ito, H. et al. Increase in radiosensitivity of lung micrometastases by hyperbaric oxygen. Clin Exp Metast 3, 21–27 (1985). https://doi.org/10.1007/BF01758951

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  • DOI: https://doi.org/10.1007/BF01758951

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