Advertisement

Annals of Hematology

, Volume 69, Issue 1, pp 41–43 | Cite as

Hyperphosphatemia in multiple myeloma

  • S. Oren
  • A. Feldman
  • S. Turkot
  • G. Lugassy
Case Report

Summary

We report three cases of IgG kappa multiple myeloma with pseudohyperphosphatemia. The patients' serum calcium levels were normal, and the hyperphosphatemia was not related to impaired renal function. No hypoparathyroidism was found, and no exogenous phosphate preparation had been given. Since the hyperphosphatemia was of no obvious clinical or physiological significance, as evidenced by normal serum levels of 1,25 dihydroxy vitamin D3, it was diagnosed as spurious and was connected to interference of the paraprotein with the chromogenic assay. In two of the patients major fluctuations in serum phosphate levels were seen, induced by the changes in globulin and paraprotein levels that occurred during therapy and relapse.

Key words

Multiple myeloma Hyperphosphatemia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Defronzo RA, Cooke CP, Wright JR et al. (1978) Renal function in patients with multiple myeloma. Medicine 57:151–166Google Scholar
  2. 2.
    Kyle RA (1975) Multiple myeloma: review of 869 cases. Mayo Clin Proc 50:29–40Google Scholar
  3. 3.
    Young DS, Pestaner LC, Gibberman V (1975) Effects of drugs on clinical laboratory tests. Clin Chem 21:342DGoogle Scholar
  4. 4.
    Leehey DJ, Daugirdas JT, Ing TS, Reid RW (1985) Spurious hyperphosphatemia due to hyperlipidemia. Arch Intern Med 145:743–744Google Scholar
  5. 5.
    Jarchowsky I, Beitner H, Plavnick L (1991) Spurious hyperphosphatemia in multiple myeloma. Harefuah 121:515–516Google Scholar
  6. 6.
    Busse JC, Gelbard MA, Byrenes JJ, Hellman R, Vaamonde CA (1987) Pseudohyperphosphatemia and dysproteinemia. Arch Intern Med 147:2045–2046Google Scholar
  7. 7.
    Petterson T, Hortling L, Teppo AM, Toetterman KJ, Fyhrquist F (1987) Phosphate binding by a myeloma protein. Acta Med Scand 222:89–91Google Scholar
  8. 8.
    Sonnenblick M, Eylath U, Brisk R, Eldad C, Hershko C (1986) Paraprotein interference with colorimetry of phosphate in serum of some patients with multiple myeloma. Clin Chem 32:1537–1539Google Scholar
  9. 9.
    Landowne RA (1979) Immunoglobulin interference with phosphorus and chloride determinations with the Coulter chemistry (letter). Clin Chem 25:1189–1190Google Scholar
  10. 10.
    Mandry JM, Posner MR, Tucci JR, Eil C (1991) Hyperphosphatemia in multiple myeloma due to a phosphate-binding immunoglobulin. Cancer 68:1092–1094Google Scholar
  11. 11.
    Adler SG, Laidlaw SA, Lubran MM, Kopple JD (1988) Hyperglobulinemia may spuriously elevate measured serum inorganic phosphate levels. Am J Kidney Dis 11:260–263Google Scholar
  12. 12.
    Savage D, Garrett TJ (1986) Multiple myeloma masquerading as metastatic breast cancer. Cancer 57:923–924Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • S. Oren
    • 1
  • A. Feldman
    • 1
  • S. Turkot
    • 1
  • G. Lugassy
    • 2
  1. 1.Department of Internal Medicine ABarzilai Medical CenterAshkelonIsrael
  2. 2.Institute of HematologyBarzilai Medical CenterAshkelonIsrael

Personalised recommendations