Abstract
Six lambs were anesthetized and connected in venouvenous mode to a Membrane Lung for Extracorporeal CO2 removal. The animals underwent several hours periods of continuous positive pressure ventilation (CPPV), at 5 cmH2O positive end expiratory pressure (PEEP), alternated with several hours periods of low frequency positive pressure ventilation (5 cmH2O PEEP, 2 b.p.m.) with extracorporeal CO2 removal (LFPPV-ECCO2R). During LFPPV-ECCO2R compared with CPPV, cardiac output increased by 26%, pulmonary vascular resistances and systemic vascular resistances decreased by 28% and 22% respectively. The renal function improved significantly during LFPPV-ECCO2R compared with CPPV, i.e. urinary flow, creatinine clearance and osmolar clearance increased by 50%, 37% and 52% respectively. In these experiments LFPPV-ECCO2R, a form of completely artificial ventilation, seems to prevent hemodynamic and renal complications of CPPV.
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This work was supported by a special Project on Biomedical Engineering, C.N.R. Rome, Contract No. 77.006.30.86 and Contract No. 77.00614.86
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Gattinoni, L., Agostoni, A., Damia, G. et al. Hemodynamics and renal function during low frequency positive pressure ventilation with extracorporeal CO2 removal. Intensive Care Med 6, 155–161 (1980). https://doi.org/10.1007/BF01757297
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DOI: https://doi.org/10.1007/BF01757297