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Characteristics of the distribution of lectin receptors in intrahepatic cholangiocellular carcinoma

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Summary

The receptors of peanut agglutinin (PNA),Dolichos biflorus agglutinin (DBA) andUlex europaeus agglutinin I (UEA-I) were localized in intrahepatic cholangiocellular carcinoma, hepatocellular carcinoma, intrahepatic bile ducts and normal, cirrhotic and pericarcinomatous liver using the avidin—biotin—peroxidase complex method. It was found that epithelial cells of normal bile ducts had many UEA-I receptors, fewer DBA receptors and no PNA receptors. The positive rates of PNA, UEA-I and DBA receptors in 18 cases of intrahepatic cholangiocellular carcinoma were 88.9%, 61.1% and 33.3% respectively, which were significantly higher than those in hepatocellular carcinoma (16.0%, 4.0% and 4.0% respectively). Hepatocytes in normal, cirrhotic and pericarcinomatous liver had no receptors for these three lectins. It is suggested that lectin receptor distribution in intrahepatic cholangiocellular carcinoma is obviously different from that in normal bile duct cells and in hepatocellular carcinoma, and might be used as an auxiliary index in its clinical diagnosis.

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Authors and Affiliations

  1. Institute of Hepatobiliary Surgery, Changhai Hospital, 174 Changhai Road, Shanghai, People's Republic of China

    Shimin Zhang, Mengchao Wu, Han Chen, Xiuzhong Zhang, Wenming Cong & Hongkui Sho

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  1. Shimin Zhang
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  2. Mengchao Wu
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  3. Han Chen
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  4. Xiuzhong Zhang
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  5. Wenming Cong
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  6. Hongkui Sho
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Zhang, S., Wu, M., Chen, H. et al. Characteristics of the distribution of lectin receptors in intrahepatic cholangiocellular carcinoma. Histochem J 21, 296–300 (1989). https://doi.org/10.1007/BF01757183

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  • DOI: https://doi.org/10.1007/BF01757183

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