Summary
A group of 16 sarcoma patients with suspected advanced disease were studied with a radiolabeled anti-sarcoma monoclonal antibody (mAb 19–24) in an attempt to localize tumor deposits. All 16 patients received125I-mAb 19–24 and then had external-probe analysis and imaging performed. Confirmation of tumor deposits was done at surgery or by autopsy. Tissues were studied in surgical patients when possible and analyzed for radioactivity, and tumor-to-blood ratios ranged from 0.6 to 36.8. In conjunction with the patients previously studied, probe results had an overall sensitivity of 83.3% and an overall specificity of 100%; scintigraphic results showed an overall sensitivity of 78.9% and an overall specificity of 100%. Radiolabeled mAb 19–24 may be developed into a useful tool for clinical immunodetection of sarcoma deposits.
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This study is supported by American Cancer Society (Illinois Division) grant 88-53
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Greager, J.A., Chao, TC., Brown, J.M. et al. Localization of human sarcoma with radiolabeled monoclonal antibody — a follow-up report. Cancer Immunol Immunother 33, 341–345 (1991). https://doi.org/10.1007/BF01756600
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DOI: https://doi.org/10.1007/BF01756600