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Cancer Immunology, Immunotherapy

, Volume 33, Issue 5, pp 341–345 | Cite as

Localization of human sarcoma with radiolabeled monoclonal antibody — a follow-up report

  • John A. Greager
  • Tzu-Chieh Chao
  • John M. Brown
  • Dan G. Pavel
  • Micheal J. Blend
  • Tapas K. Das Gupta
Original articles
  • 16 Downloads

Summary

A group of 16 sarcoma patients with suspected advanced disease were studied with a radiolabeled anti-sarcoma monoclonal antibody (mAb 19–24) in an attempt to localize tumor deposits. All 16 patients received125I-mAb 19–24 and then had external-probe analysis and imaging performed. Confirmation of tumor deposits was done at surgery or by autopsy. Tissues were studied in surgical patients when possible and analyzed for radioactivity, and tumor-to-blood ratios ranged from 0.6 to 36.8. In conjunction with the patients previously studied, probe results had an overall sensitivity of 83.3% and an overall specificity of 100%; scintigraphic results showed an overall sensitivity of 78.9% and an overall specificity of 100%. Radiolabeled mAb 19–24 may be developed into a useful tool for clinical immunodetection of sarcoma deposits.

Key words

Human sarcoma Radiolabeled antibody 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • John A. Greager
    • 1
    • 3
  • Tzu-Chieh Chao
    • 1
    • 3
  • John M. Brown
    • 1
    • 3
  • Dan G. Pavel
    • 1
    • 3
  • Micheal J. Blend
    • 2
  • Tapas K. Das Gupta
    • 1
    • 3
  1. 1.Division of Surgical Oncology, Department of SurgeryUniversity of Illinois College of Medicine at ChicagoChicagoUSA
  2. 2.Division of Nuclear MedicineMichael Reese HospitalChicagoUSA
  3. 3.West Side Veterans Administration HospitalCook County Hospital, and the Hektoen Institute for Medical ResearchChicagoUSA

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