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Untersuchungen zur indirekten sympathomimetischen Wirkung von Angiotensin an isolierten Blutgefäßen

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Zusammenfassung

Es wird über Versuche zum Wirkungsmechanismus von Angiotensin an Aortenstreifenpräparaten von Ratten berichtet.

Nach Bespülung mit Angiotensin war der Noradrenalingehalt der Präparate signifikant vermindert.

Kontraktionsmessungen ergaben, daß nach länger dauernder oder wiederholter Angiotensinbespülung eine vollständige Tachyphylaxie eintrat, die sich durch zwischenzeitliche Noradrenalinbespülung wieder durchbrechen ließ.

Zwischen Angiotensin und Tyramin bestand eine gekreuzte Tachyphylaxie.

Cocain schwächte die Angiotensinwirkung ab und verhinderte die Wiederherstellung der Angiotensinwirkung durch Noradrenalin. Nach Vorbehandlung der Tiere mit Reserpin entwickelte sich die Angiotensintachyphylaxie in kürzerer Zeit.

Die Ergebnisse werden mit einer indirekten vasoconstrictorischen Wirkung von Angiotensin erklärt, die an die Gegenwart von freisetzbarem Noradrenalin in den terminalen sympathischen Nervenfasern der Gefäßwand gebunden ist.

Summary

Studies on the mode of action of angiotensin were performed in aortic strip preparations of rats.

Rinsing with angiotensin caused a significant decrease of the content of noradrenaline of the preparations.

Studies of the mechanical pattern of the preparations revealed the development of a complete tachyphylaxis during continuous or repeated application of angiotensin. Angiotensin regained its activity after temporary application of noradrenaline.

There was a crossed tachyphylaxis between angiotensin and tyramine.

Application of cocaine caused a diminished effect of angiotensin and prevented the restitution of the effect of angiotensin by noradrenaline.

After pretreatment of the animals with reserpine there was an accelerated development of angiotensin tachyphylaxis.

It is concluded that there is an indirect vasoconstrictor action of angiotensin dependent on “available” noradrenaline in the adrenergic terminals of the vessel wall.

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Authors and Affiliations

  1. II. Medizinische Klinik und Poliklinik und I. Physiologisches Institut der Universität des Saarlandes in Homburg/Saar, Germany

    H. Liebau, A. Distler, H. P. Wolff, A. Köhler & D. Sandt

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  1. H. Liebau
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  2. A. Distler
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  3. H. P. Wolff
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  4. A. Köhler
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  5. D. Sandt
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Herrn Professor Dr.H. Schwiegk zum 60. Geburtstag gewidmet.

Mit Unterstützung der Deutschen Forschungsgemeinschaft.

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Liebau, H., Distler, A., Wolff, H.P. et al. Untersuchungen zur indirekten sympathomimetischen Wirkung von Angiotensin an isolierten Blutgefäßen. Klin Wochenschr 44, 322–326 (1966). https://doi.org/10.1007/BF01752280

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