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Molecular evolution of snake venom toxins

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Summary

Phylogenetic trees were constructed for 62 venom toxins of snakes ofProteroglyphae suborder using matrix method. The resulting tree fromMinimum Spanning Tree-Cluster Analysis technique had the lowest “percent deviation” (8.55). The taxonomic relationship of these toxins agrees very well with zoological opinions. However, the appearance of the tree did not directly provide a plausible evolutionary model for the toxins. A model was derived from nodal ancestral sequence calculations, comparisons between intra-and inter-generical rates of amino acid change, and generally held ideas about protein evolution. According to the model, short neurotoxin is the ancient form of snake venom toxins. The courses of evolution leading to the present intraspecific homologous toxins are explained by gene duplication and allelomorphism.

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Hseu, T.H., Jou, E.D., Wang, C. et al. Molecular evolution of snake venom toxins. J Mol Evol 10, 167–182 (1977). https://doi.org/10.1007/BF01751810

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