Summary
Hydrocortisone hemisuccinate within 4 hours afterin vivo administration produces an increase in precursor incorporation into rat thymus RNA and proteins in the whole animal. From these results, together with information obtained from measurements of the tyrosine aminotransferase activity and the action of mitomycin C administered one hour before the injection of hydrocortisone, it can be concluded that the increase in tissue level of the enzyme, consequent to hydrocortisone treatment, results from an increased rate of biosynthesis of the enzyme, which participates in the catabolic processes of proteins in glucocorticoid sensitive thymus cells.
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Abraham, A.D. L-tyrosine: 2-oxoglutarate aminotransferase induction by hydrocortisone in the thymus of the white RAT. Mol Cell Biochem 9, 131–133 (1975). https://doi.org/10.1007/BF01751307
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DOI: https://doi.org/10.1007/BF01751307