Zusammenfassung
Unter Behandlung mit einem Ovulationshemmer (17α-Äthyl-19-nortestosteron-acetat + Äthinyloestradiol, „Anovlar-21“) wurde eine Erhöhung freier und konjugierter 17-OH-CS im Plasma nachgewiesen. Des weiteren kam es zu einer Abnahme der 17-KS und der freien und konjugierten Oestrogene im Blut. Nach Absetzen des Medikaments trat eine weitgehende Normalisierung der Steroidkonzentrationen im Plasma ein.
Summary
Under treatment with 17α-Äthinyl-19-nortestosteron-acetat + Äthinyloestradiol (“Anovlar-21”) an increase of free and conjugated 17-OH-CS in plasma could be detected. Furthermore, a decrease of 17-KS and free and conjugated estrogens in blood was observed. After cessation of therapy all steroids levels tended to return to normal concentrations.
This is a preview of subscription content, log in via an institution to check access.
Literatur
Buchholz, R., L. Nocke, andW. Nocke: The influence of gestagens on the urinary excretion of pituitary gonadotropins, estrogens, and pregnanediol in women in the postmenopause and during the menstrual cycle. Int. J. Fertility9, 231 (1964).
Loraine, J. A., E. T. Bell, .R A. Harkness, E. Mears, andM. C. N. Jackson: Oral progestational agents. Effects of long term administration on hormone excretion in normally menstruating women. Lancet1963, 902.
Peeters, F., M. van Roy etH. Oeyen: Inhibition de l'ovulation par gestagènes. Scalpel (Brux.)114, 1111 (1961).
Holmes, R. L., andA. M. Mandl: Oral contraceptives. An assessment of their mode of action. Lancet1962, 1174.
Brown, J. B., K. Fotherby, andJ. Aa. Loraine: The effect of norethisterone and its acetate on ovarian and pituitary function during the menstrual cycle. J. Endocr.25, 331 (1962).
Wallach, E. E., C. M. Garcia, W. Kistner, andG. Pincus: Plasma corticosteroid levels in women receiving oral contraceptive tablets. Amer. J. Obstet. Gynec.87, 991 (1963).
Breuer, H.: Studies on the metabolism of 17α-ethinyl-19-nortestosterone. Int. J. Ferility9, 181 (1964).
Engel, L. L., W. R. Slaunwhite, P. Carter, andI. T. Nathanson: The separation of natural estrogens by counter current distribution. J. biol. Chem.185, 255 (1950).
Porter, C. C., andR. H. Silber: A quantitative color reaction for cortisone and related 17,21-dihydroxy-20-ketosteroids. J. biol. Chem.185, 201 (1950).
Zimmermann, W.: Eine Farbreaktion der Sexualhormone und ihre Anwendung zur quantitativen colorimetrischen Bestimmung. Hoppe-Seylers Z. physiol. Chem.233, 257 (1935).
Ceresa, F., andA. Cravetto: A method for the simultaneous assay of 17-hydroxycorticosteroids and 17-ketosteroids both in their free and conjugated form on the same plasma sample. Acta endocr. (Kbh.)29, 321 (1958).
Ittrich, G.: Eine Methode zur chemischen Bestimmung von oestrogenen Hormonen in Blut, Milch und Colostrum. Hoppe-Seylers Z. physiol. Chem.320, 103 (1960).
Oertel, G. W.: Oestrogen-Bestimmungen. I. Bestimmung von Gesamtoestrogenen im Plasma. Clin. chim. Acta6, 237 (1961).
Slaunwhite, W. R., andA. A. Sandberg: Transcortin: a corticosteroid-binding protein of plasma. J. clin. Invest.38, 384 (1959).
Daughaday, W. H., andI. K. Mariz: The binding of steroid hormones by plasma proteins. In: Biological activity of steroids in relation to cancer, p. 61. New York and London: Academic Press 1960.
Westphal, U.: Interaction between steroids and proteins. In: Mechanism of action of steroid hormones (C. A. Villee andL. L. Engel Ed.), p. 33. Oxford-London-New York: Pergamon Press 1961.
Sandberg, A. A., andW. R. Slaunwhite: Transcortin: a corticosteroid-binding protein of plasma. II. Levels in various conditions and the effect of estrogens. J. clin. Invest.38, 1290 (1959).
Carter, A. C., E. B. Feldman, andE. Z. Wallace: The effects of steroids on the levels of the plasma 17-hydroxycorticosteroids and the serumprotein-bound iodine. In: Biological activity of steroids in relation to cancer (G. Pincus andE. P. Vollmer Ed.), p. 77. New York and London: Academic Press 1960.
Brown, J. B., K. Fotherby, andJ. A. Loraine: Effect of 17α-ethinyl-19-nortestosterone on the urinary excretion of estrogens, pregnanediol, and gonadotropins during the menstrual cycle. Proc. roy. Soc. Med.53, 431 (1960).
Feldman, E. B., andA. C. Carter: Endocrinologic and metabolic effects of 17α-methyl-19-nortestosterone in women. J. clin. Endocr.20, 842 (1960).
Buchholz, R.: Untersuchungen über die Beeinflussung der Gonadtropinausscheidung beim Menschen durch Keimdrüsenhormone. Geburtsh. u. Frauenheilk.19, 851 (1959).
Miyake, T., andF. Kobayashi: Effects of norethisterone and certain other steroids on the female gonads of hypophysectomized immature rats. Endocr. jap.7, 215 (1960).
Gesenius, H.: Orale Empfängnisverhütung. Wirkungsmechanismus, Bedenken, Nebenerscheinungen. Med. Klin.58, 897 (1963).
Overbeck, G.A., andJ. de Visser: Different modes of action of two anovulatory compounds. Acta endocr. (Kbh.), Suppl.90, 179 (1964).
Vande Wiele, R.I., P.C. MacDonald, E. Bolte, andS. Lieberman: Precursors of the urinary 11-deoxy-17-ketosteroids: Estimation of the secretory rate of dehydroisoandrosterone. J. clin. Endocr.22, 107 (1962).
MacDonald, P. C., R. I. Vande Wiele, andS. Lieberman: Precursors of the urinary 11-deoxy-17-ketosteroids. II. Influence of the level of secretion of dehydroisoandrosterone on the determination of its secretory rate. J. clin. Endocr.22, 1222 (1962).
Shteri, P. K., andS. Lieberman: In-vivostudies with radioactive steroid conjugates. I. The fate of randomly tritiated androsterone glucuronoside in humans. Biochemistry2, 1171 (1963).
Eik-Nes, K. B., G. W. Oertel, R. Nimer, andF. H. Tyler: Effect of human chorionic gonadotropin on plasma concentrations of 17-hydroxycorticosteroids, dehydroepiandrosterone and androsterone. J. clin. Endocr.19, 1405 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gontermann, D., Oertel, G.W. Zur Wirkung eines Ovulationshemmers auf Plasma-Steroide. Klin Wochenschr 44, 276–279 (1966). https://doi.org/10.1007/BF01747719
Issue Date:
DOI: https://doi.org/10.1007/BF01747719