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Die Adjuvanswirkung von Mycobakterien

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Zusammenfassung

Die Bedeutung der Mycobakterien als Adjuvantien wird besprochen. Die Sonderstellung des mycobakteriellen Adjuvans ergibt sich daraus, daß es nicht nur die Fähigkeit besitzt, die Bildung zirkulierender Antikörper gegenüber einem Antigen zu steigern, sondern daß es darüber hinaus auch gegen dieses Antigen den verzögerten Typus der Empfindlichkeit auslöst. Eine besondere Bedeutung kommt den Mycobakterien bei der „Komplettierung“ von Wasser-in-Ö1-Emulsionen zu. Abschließend wird die Frage untersucht, auf welche bakteriellen Strukturen sich die Adjuvans-Wirkung zurückführen läßt.

Summary

The importance of mycobacteria as immunological adjvants is discussed. The peculiarity of the mycobacterial adjuvant is based on the potency to enhance the production of circulating antibodies to an antigen and to induce the delayed type of sensitivity. Mycobacteria are highly useful for the „completion“ of water-in-oil-emulsions. The question is considered to which bacterial structures the adjuvant potency can be connected.

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Finger, H. Die Adjuvanswirkung von Mycobakterien. Klin Wochenschr 44, 1105–1111 (1966). https://doi.org/10.1007/BF01745533

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