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Vergleich der hämodynamischen Wirkungen vonD-Sotalol undD,L-Sotalol

Comparison of the hemodynamic effects ofD-sotalol andD,L-sotalol

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Summary

The hemodynamic effects of the class III drugD-sotalol and of the beta adrenergic receptor antagonistD,L-sotalol were compared in 16 rats (2 mg/kg i.v.). A group with NaCl-infusion served as control (n=10). Besides measurements in the intact circulation isovolumic registrations were performed to examine the left ventricular myocardial function without interferences.D,L-sotalol significantly reduced the dp/dtmax (61%) and the peak isovolumic left ventricular pressure (64%). It lowered the heart rate by 13% and slightly increased the mean aortic pressure to 107% (p<0.05).D-sotalol, in contrast, caused only a very transient reduction of the dp/dtmax and was comparable to the controls already 5 min after injection. The results demonstrate, that theD-enantiomer is largely avoid of the hemodynamic effects of the racemicD,L-sotalol after intravenous injection.

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Abbreviations

LVP:

systolischer linksventrikulärer Druck

EDP:

enddiastolischer linksventrikulärer Druck

AoPm:

mittlerer Aortendruck

peak LVSP:

maximaler isovolumetrischer linksventrikulärer Druck

peak dp/dtmax:

höchstes dp/dtmax bei isovolumetrischer Messung

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Authors and Affiliations

  1. Medizinische Klinik, Abteilung III, Universität Tübingen, Germany

    H. M. Hoffmeister & L. Seipel

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  1. H. M. Hoffmeister
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  2. L. Seipel
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Hoffmeister, H.M., Seipel, L. Vergleich der hämodynamischen Wirkungen vonD-Sotalol undD,L-Sotalol. Klin Wochenschr 66, 451–454 (1988). https://doi.org/10.1007/BF01745517

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  • DOI: https://doi.org/10.1007/BF01745517

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