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Hyaluronidase-, β-Glucuronidase- und β-Acetylglucosaminidase-Aktivität im menschlichen Serum während der Schwangerschaft

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Zusammenfassung

In 260 menschlichen Seren wurden im Verlauf der Schwangerschaft, post partum und im Nabelvenenserum die Aktivitäten der Hyaluronidase,β-Glucuronidase undβ-Acetylglucosaminidase gemessen. Dabei zeigte sich für alle drei lysosomalen Enzyme ein deutlicher Aktivitätsanstieg bis zur Geburt, nach der Entbindung wieder ein Abfall der Enzymaktivitäten. Durch Messung der Enzymaktivitäten im Nabelvenenserum konnte die Placentargängigkeit ausgeschlossen werden. Die Ursache der erhöhten Glykosaminoglykano-Hydrolasenaktivitäten und ihre Bedeutung für den Geburtsmechanismus wurden diskutiert.

Summary

The activities of Hyaluronidase,β-Glucuronidase andβ-Acetylglucosaminidase were measured in 260 human sere during pregnancy, post partum and in the umbilical cord serum. All three lysosomal enzymes increased with pregnancy and showed a decrease post partum. The enzyme activity in the umbilical cord showed that the enzymes could not pass the placenta. Source of the glycosaminoglycan-hydrolases and function for birth mechanism was discussed.

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  1. Medizinische Kliniken und Polikliniken und Frauenklinik der Justus Liebig-Universität Gießen, Germany

    D. Platt & M. Platt

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Platt, D., Platt, M. Hyaluronidase-, β-Glucuronidase- und β-Acetylglucosaminidase-Aktivität im menschlichen Serum während der Schwangerschaft. Klin Wochenschr 46, 768–771 (1968). https://doi.org/10.1007/BF01745491

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