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Improved detection of acute myocardial infarction by magnetic resonance imaging using Gadolinium-DTPA

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Summary

To assess the value of the paramagnetic contrast agent Gadolinium (Gd)-DTPA in Magnetic Resonance Imaging (MRI) of acute myocardial infarction (AMI), we studied 20 patients with a first AMI by ECG-gated MRI before and after intravenous administration of 0.15mmol/kg Gd-DTPA. The MRI studies were performed after a mean of 98 hours (range 15–241) after the acute onset of AMI. Spin-echo measurements (TE 30 msec) were made using a Philips Gyroscan (0.5 Tesla). After performing the baseline MRI scans, the MRI procedure was repeated every 10 minutes for up to 40 minutes following injection of Gd-DTPA. In 18 (90%) patients contrast enhancement in the infarcted myocardial areas was observed after Gd-DTPA. In these patients intensity versus region curves, derived from 9 to 11 adjacent myocardial regions of interest, showed increased signal intensities in the infarcted areas after administration of Gd-DTPA. The precontrast signal intensity ratio between infarcted and normal myocardium was 1.14±0.15 (mean±SD); the postcontrast ratios at 10 minutes were 1.41±0.21 (P <0.05), at 20 minutes 1.61±0.19 (P <0.01), at 30 minutes 1.43±0.20 (P < 0.05), and at 40 minutes 1.33±0.20 (P=NS). It is concluded that MRI using the contrast agent Gd-DTPA significantly improves the visualization and detection of infarcted myocardial areas in patients with AMI and that optimal contrast enhancement is obtained 20 minutes after administration of Gd-DTPA.

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Authors and Affiliations

  1. Departments of Cardiology, University Hospital Leiden, The Netherlands

    Paul R. M. van Dijkman, Arnoud van der Laarse, Albert V. G. Bruschke, Volkert Manger Cats & Ernst E. van der Wall

  2. Diagnostic Radiplogy, University Hospital Leiden, The Netherlands

    Joost Doornbos, Albert de Roos, Sandra Postema & Ad E. van Voorthuisen

  3. Interuniversity Cardiology Institute Netherlands, The Netherlands

    Niels A. A. Matheijssen

Authors
  1. Paul R. M. van Dijkman
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  2. Joost Doornbos
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  3. Albert de Roos
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  4. Arnoud van der Laarse
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  5. Sandra Postema
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  6. Niels A. A. Matheijssen
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  7. Albert V. G. Bruschke
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  8. Ad E. van Voorthuisen
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  9. Volkert Manger Cats
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  10. Ernst E. van der Wall
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van Dijkman, P.R.M., Doornbos, J., de Roos, A. et al. Improved detection of acute myocardial infarction by magnetic resonance imaging using Gadolinium-DTPA. Int J Cardiac Imag 5, 1–8 (1989). https://doi.org/10.1007/BF01745226

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  • DOI: https://doi.org/10.1007/BF01745226

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