Heart and Vessels

, Volume 10, Issue 4, pp 178–184 | Cite as

Vitamin E prevents endothelial injury associated with cisplatin injection into the superior mesenteric artery of rats

  • Hiroyuki Ito
  • Tatsumasa Okafuji
  • Tsuneyuki Suzuki


To clarify the pathogenesis of the vascular injury caused by the administration of anti-neoplastic drugs, cisplatin with lipiodol was infused into the superior mesenteric artery of rats. Morphological and biochemical changes in the vascular wall and the prophylactic effects of vitamin E were examined 4 days after administration. In the cisplatin-treated group, but not in the other groups, severe endothelial injury, such as vacuolation, subendothelial edema, and destruction of the internal elastic membrane, was observed. Superoxide dismutase, a potent scavenger of the superoxide anion, was markedly lower in the cisplatin group, and Na/K-ATPase, a marker of the plasma membrane, was also low in this group. These morphological changes were minimal, and enzyme activity was higher in the vitamin E-treated group than in the cisplatin-treated group. These findings indicate that endothelial injury after cisplatin administration could be caused by free radical-induced lipid peroxidation of the membrane system, and that such injury may be prevented by the co-administration of vitamin E.

Key words

Endothelial cell Free radical Superoxide dismutase Lipid peroxidation Vitamin E 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Hiroyuki Ito
    • 1
  • Tatsumasa Okafuji
    • 2
  • Tsuneyuki Suzuki
    • 3
  1. 1.Division of Pathology, Research Institute of HypertensionKinki University School of MedicineOsakaJapan
  2. 2.Department of RadiologyKinki University School of MedicineOsakaJapan
  3. 3.Department of PathologyKinki University School of MedicineOsakaJapan

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