Heart and Vessels

, Volume 7, Supplement 1, pp 116–119 | Cite as

Left ventricular dysfunction and HLA Bw52 antigen in Takayasu arteritis

  • Kenji Kasuya
  • Yuji Hashimoto
  • Fujio Numano


Heart disease is the main cause of death in patients with Takayasu arteritis. It has been reported that this disease is closely related to the presence of HLA Bw52 antigen. To assess the correlation between this antigen and left ventricular involvement, we studied 40 patients with Takayasu arteritis, 21 with and 19 without Bw52, using Tl-201 stress myocardial scintigraphy and echocardiography. Those with Bw52 had a significantly higher incidence of abnormal electrocardiographic findings (67% vs 26%;P < 0.05) and of aortic regurgitation (52% vs 11%;P < 0.05). The echocardiographically determined interventricular septal wall thickness plus left ventricular posterior wall thickness (25 ± 8 vs 17 ± 3 mm;P < 0.01) and the left ventricular mass (257 ± 132 vs 142 ± 51 g;P < 0.01) were significantly increased in the patients with Bw52. Scintigraphically determined perfusion abnormalities were significantly more frequent in those with Bw52 (76% vs 32%;P < 0.05).

These observations indicate that patients with Takayasu arteritis and Bw52 antigen have a more severe left ventricular involvement than the patients without that antigen. The left ventricular impairment may account for the poor prognosis of Takayasu patients with Bw52.

Key words

Takayasu arteritis HLA Antigen Tl201 Scintigraphy Echocardiography 


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  1. 1.
    Report of Committee on Study of Arteritis, Japanese Ministry of Education (1968) Clinical and pathological studies of aortic syndrome. Jpn Heart J 9:76–87Google Scholar
  2. 2.
    Lupi-Herrera E, Sanchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE (1977) Takayasu's arteritis. Clinical study of 107 cases. Am Heart J 93:94–103PubMedGoogle Scholar
  3. 3.
    Ishikawa K (1978) Natural history and classification of occlusive thromboaortopathy (Takayasu's disease) Circulation 57:27–35PubMedGoogle Scholar
  4. 4.
    Marooka S, Saito Y, Nonaka Y, Gyotoku Y, Sugimoto T (1984) Clinical features and course of aortitis syndrome in Japanese women older than 40 years. Am J Cardiol 53:859–861PubMedGoogle Scholar
  5. 5.
    Ishikawa K (1988) Diagnostic approach and proposed criteria for the clinical diagnosis of Takayasu's arteriopathy. J Am Coll Cardiol 12:964–972PubMedGoogle Scholar
  6. 6.
    Numano F, Isohisa I, Kishi Y, Arita M, Maezawa H (1978) Takayasu's disease in twin sisters. Possible genetic factors. Circulation 58:173–177PubMedGoogle Scholar
  7. 7.
    Isohisa I, Numano F, Maezawa H, Sasazuki T (1978) HLA-Bw52 in Takayasu's disease. Tissue Antigens 12:246–248PubMedGoogle Scholar
  8. 8.
    Numano F, Isohisa I, Maezawa H, Juji T (1979) HLA antigens in Takayasu's disease. Am Heart J 98:153–157Google Scholar
  9. 9.
    Numano F, Ohta N, Sasazuki T (1982) HLA and clinical manifestations in Takayasu disease. Jpn Circ J 46:184–189PubMedGoogle Scholar
  10. 10.
    Isohisa I, Numano F, Maezawa H, Sasazuki T (1982) Hereditary factors in Takayasu's disease. Angiology 33:98PubMedGoogle Scholar
  11. 11.
    Yajima M, Namba K, Kakuta T, Nishizaki M, Oniki T, Numano, F (1989) Echocardiographic studies of aortic regurgitation in Takayasu arteritis. J Cardiovasc Tech 8:223–230Google Scholar
  12. 12.
    Hashimoto Y, Numano F, Maruyama Y, Oniki T, Kasuya K, Kakuta T, Wada T, Yajima M, Maezawa H (1991) Thallium-201 stress scintigraphy in Takayasu arteritis. Am J Cardiol 67:879–882Google Scholar
  13. 13.
    Romhilt DW, Estes EH (1968) A point-score analysis for the ECG diagnosis of left ventricular hypertrophy. Am Heart J 75:752–758PubMedGoogle Scholar
  14. 14.
    Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N (1986) Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings. Am J Cardiol 57:450–458PubMedGoogle Scholar
  15. 15.
    Terasaki PI, McClelland JD (1964) Microdroplet assay of human serum cytotoxins. Nature 204:998–1000Google Scholar
  16. 16.
    O'Gara PT, Bonow RO, Maron BJ, Damske BA, Lingen AV, Bacharach SL, Larsen SM, Epstein SE (1987) Myocardial perfusion abnormalities in patients with hypertrophic cardiomyopathy: Assessment with thallium-201 emission computed tomography. Circulation 76:1214–1223PubMedGoogle Scholar
  17. 17.
    Schulman DS, Francis CK, Black HR, Wackers FJ Th (1987) Thallium-201 stress imaging in hypertensive patients. Hypertension 10:16–21PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Kenji Kasuya
    • 1
  • Yuji Hashimoto
    • 1
  • Fujio Numano
    • 1
  1. 1.The Third Department of Internal MedicineTokyo Medical and Dental University, School of MedicineTokyoJapan

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