, Volume 61, Issue 4, pp 222–225 | Cite as

Patterns of contact phase proteins indicating neuropathy in diabetic patients

  • P. Meier
  • G. A. Marbet
  • W. Berger
  • F. Duckert
  • W. Friedli
Original article


In 42 outpatients of the diabetology division, coagulation and fibrinolysis variables were determined in order to detect typical patterns of results with which it was possible to discriminate between three groups with different diabetic complications (17: no complication, 7: angiopathy alone, 18: neuropathy with or without other complications). There was a statistically significant discriminatory function involving C1-inhibitor concentration, high molecular weight kininogen coagulant activity and fibrinogen as the mosts decisive variables. The neuropathy group was appropriately separated from the others with an 81% correct reclassification. Heparin cofactor II, histidine-rich glycoprotein, α2-macroglobulin, pre-kallikrein and factor XII had no discriminative power.

Key words

Coagulation factors Contact phase Fibrinolysis Diabetes mellitus Neuropathy 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • P. Meier
    • 1
  • G. A. Marbet
    • 1
  • W. Berger
    • 2
  • F. Duckert
    • 1
  • W. Friedli
    • 3
  1. 1.Coagulation and Fibrinolysis LaboratoryKantonsspitalBaselSwitzerland
  2. 2.Department of Internal Medicine, Division of Endocrinology and DiabetologyKantonsspitalBaselSwitzerland
  3. 3.Department of NeurologyKantonsspitalBaselSwitzerland

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