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, Volume 61, Issue 4, pp 222–225 | Cite as

Patterns of contact phase proteins indicating neuropathy in diabetic patients

  • P. Meier
  • G. A. Marbet
  • W. Berger
  • F. Duckert
  • W. Friedli
Original article
  • 17 Downloads

Summary

In 42 outpatients of the diabetology division, coagulation and fibrinolysis variables were determined in order to detect typical patterns of results with which it was possible to discriminate between three groups with different diabetic complications (17: no complication, 7: angiopathy alone, 18: neuropathy with or without other complications). There was a statistically significant discriminatory function involving C1-inhibitor concentration, high molecular weight kininogen coagulant activity and fibrinogen as the mosts decisive variables. The neuropathy group was appropriately separated from the others with an 81% correct reclassification. Heparin cofactor II, histidine-rich glycoprotein, α2-macroglobulin, pre-kallikrein and factor XII had no discriminative power.

Key words

Coagulation factors Contact phase Fibrinolysis Diabetes mellitus Neuropathy 

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References

  1. 1.
    Brown MJ, Asbury AK (1984) Diabetic neuropathy. Ann Neurol 15: 2–12PubMedGoogle Scholar
  2. 2.
    Christe M, Fritschi J, Lämmle B, Tran TH, Marbet GA, Duckert F (1984) Fifteen coagulation and fibrinolysis parameters in diabetes mellitus and in patients with vasculopathy. Thromb Haemostas 52: 138–43Google Scholar
  3. 3.
    Christe M, Gattlen P, Fritschi J, Lämmle B, Marbet GA, Duckert F (1984) The contact phase of coagulation in diabetes mellitus and in patients with vasculopathy. Thromb Haemostas 52: 221–3Google Scholar
  4. 4.
    Clauss A (1957) Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol 17: 237–46PubMedGoogle Scholar
  5. 5.
    Dyck PJ, Karnes JL, O'Brien P, Okazaki H, Lais A, Engelstad J (1986) The spatial distribution of fibre loss in diabetic poly-neuropathy suggests ischemia. Ann Neurol 19: 440–9PubMedGoogle Scholar
  6. 6.
    Ewing DJ, Clarke BF (1982) Diagnosis and management of diabetic autonomic neuropathy. Br Med J 285: 916–8Google Scholar
  7. 7.
    Fritschi J, Christe M, Lämmle B, Marbet GA, Berger W, Duckert F (1984) Platelet aggregation, β-thromboglobulin and platelet factor 4 in diabetes mellitus and in patients with vasculopathy. Thromb Haemostas 52: 236–9Google Scholar
  8. 8.
    Gram J, Jespersen J, Kold A (1988) Effects of an oral antidiabetic drug on the fibrinolytic system of blood in insulin-treated diabetic patients. Metabolism 37: 937–943PubMedGoogle Scholar
  9. 9.
    Gram J, Jespersen J (1989) Increased concentrations of heparin cofactor II in diabetic patients, and possible effects on thrombin inhibition assay of antithrombin III. Clin Chem 35: 52–55PubMedGoogle Scholar
  10. 10.
    Landgraf-Leurs MMC, Ladik T, Smolka B, Bock T, Schramm W, Spannagl M, Landgraf R (1987) Increased thromboplastic potential in diabetes: a multifactorial phenomenon. Klin Wochenschr 65: 600–606PubMedGoogle Scholar
  11. 11.
    Laurell CB (1966) Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 15: 45–52PubMedGoogle Scholar
  12. 12.
    Patrassi GM, Vettor R, Padovan D, Girolami A (1982) Contact phase of blood coagulation in diabetes mellitus. Eur J Clin Invest 12: 307–11PubMedGoogle Scholar
  13. 13.
    Patrassi GM, Martinelli S, Picchinenna A, Girolami A (1985) Contact phase of coagulation in diabetes mellitus after aspirin administration. Folia Haematol 112: 333–338Google Scholar
  14. 14.
    Scott CF, Silver LD, Schapira M, Colman RW (1984) Cleavage of human high molecular weight kininogen markedly enhances its coagulant activity. Evidence that this molecule exists as a profactor. J Clin Invest 73: 954–962PubMedGoogle Scholar
  15. 15.
    Tran TH, Duckert F (1984) Heparin cofactor II determination — levels in normals and patients with hereditary antithrombin III deficiency and disseminated intravascular coagulation. Thromb Haemostas 52: 112–6Google Scholar
  16. 16.
    Uehara S, Isogawa S, Sakamoto W, Hirayama A (1988) Kallikrein-kinin system in diabetic patients. Arzneimittelforsch 38: 721–723PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • P. Meier
    • 1
  • G. A. Marbet
    • 1
  • W. Berger
    • 2
  • F. Duckert
    • 1
  • W. Friedli
    • 3
  1. 1.Coagulation and Fibrinolysis LaboratoryKantonsspitalBaselSwitzerland
  2. 2.Department of Internal Medicine, Division of Endocrinology and DiabetologyKantonsspitalBaselSwitzerland
  3. 3.Department of NeurologyKantonsspitalBaselSwitzerland

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