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Cancer Immunology, Immunotherapy

, Volume 31, Issue 1, pp 49–52 | Cite as

Interleukin-6 enhances the induction of human lymphokine-activated killer cells

  • G. Gallagher
  • W. H. Stimson
  • J. Findlay
  • F. Al-Azzawi
Original articles

Summary

Human peripheral blood mononuclear cells develop a powerful lytic capacity when cultured in vitro with interleukin-2 (IL-2), becoming lymphokine-activated killer cells (LAK cells). As part of an investigation into means of influencing this process, the effect of other cytokines has been examined. In this study we describe the ability of interleukin-6 (IL-6) to regulate the induction and function of human LAK cells. The results show that substitution of IL-6 for IL-2 did not lead to the development of functional LAK cells, nor was IL-6 able to alter the lytic capacity of established LAK cells. However, when IL-6 was included with IL-2 during the induction phase of the LAK cells, the resulting cells displayed considerably greater lytic activity than those prepared with IL-2 alone. This effect was IL-6 dose-related. These results indicate that LAK cell development may be positively regulated in vitro; the implications of this observation for the clinical usage of LAK cells are discussed.

Keywords

Cancer Research Mononuclear Cell Peripheral Blood Mononuclear Cell Killer Cell Cell Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • G. Gallagher
    • 1
  • W. H. Stimson
    • 1
  • J. Findlay
    • 2
  • F. Al-Azzawi
    • 2
  1. 1.Immunology DivisionUniversity of Strathclyde, The Todd CentreGlasgowUK
  2. 2.Addenbrookes HospitalUniversity of CambridgeCambridgeUK

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