Klinische Wochenschrift

, Volume 62, Issue 9, pp 417–422 | Cite as

Langzeitbeobachtung bei 15 Patienten mit differenziertem Schilddrüsenkarzinom und unklar erhöhten Plasmathyreoglobulinspiegeln (Tg)

  • H. -P. Stumpf
  • M. Hüfner
  • H. -J. Hermann
  • B. Kimmig

Long-term follow-up of 15 patients with differentiated thyroid cancer and elevated plasma thyroglobulin levels without evidence of recurrence


The follow-up of 15 patients with differentiated cancer of the thyroid was analysed retrospectively. All patients had persistent or developed elevated thyroglobulin (Tg) plasma levels (>10 ng/ml) after total thyroidectomy and 131 I therapy. There was no evidence of thyroid remnants or metastases in the 131 I whole body scan, bone scan, chest X-ray or clinical investigation. Nine of 15 patients developed local or distant metastases during a follow-up period of 3–39 months (mean=18 months). Only one of seven recurrences tested were 131 I positive, Tg values of 9 from 12 patients showed no correlation to the Thyroid-stimulating hormone (TSH) level. It is concluded that: (1) this group of patients is at high risk of developing a recurrence (2) new methods have to be developed for the localization of 131 I negative but Tg positive metastases.

Key words

Plasma thyroglobulin Thyroid cancer 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • H. -P. Stumpf
    • 1
  • M. Hüfner
    • 1
  • H. -J. Hermann
    • 2
  • B. Kimmig
    • 2
  1. 1.Medizinische Universitäts-PoliklinikGermany
  2. 2.Universitäts-Strahlenklinik HeidelbergGermany

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