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Klinische Wochenschrift

, Volume 62, Issue 9, pp 394–398 | Cite as

Serum gentamicin concentrations during intratracheal administration

  • F. Vogel
  • M. Exner
  • H. v. Lilienfeld-Toal
  • N. Cattelaens
  • M. Eichelbaum
Originals

Summary

In artificially ventilated patients, intratracheal aminoglycoside administration is used as a form of prophylaxis of broncho-pulmonary infections. In artificially ventilated patients with multiple organ failure, serum gentamicin concentrations were measured dependent on renal function after endotracheal administration. A standard commercial ampule of 40 mg gentamicin in a 1 ml solution was injected in undiluted form, intratracheally through the tubus, every 6 h. In the patients without renal failure, values over 1 µg/ml were only found in certain individual cases and reached a maximum of 1.5 µg/ml. In patients with renal failure even after prolonged application, the average serum concentrations were between 2 and 3.5 µg/ml. In a very few cases, however, levels of up to 10.5 µg/ml were measured. The daily serum pattern revealed a distinct dependence on the administration; 1 h after administration there was an increase in the serum concentrations which decreased to the initial levels after 6 h. When patients with renal impairment are given an aminoglycoside intratracheally, serum levels of up to 10.5 µg/ml may be reached and thus additional systemic aminoglycoside therapy should be avoided.

Key words

Gentamicin serum concentration Intratracheal administration 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • F. Vogel
    • 1
  • M. Exner
    • 1
  • H. v. Lilienfeld-Toal
    • 1
  • N. Cattelaens
    • 1
  • M. Eichelbaum
    • 1
  1. 1.Medizinische Klinik und Hygiene-Institut der Universität BonnGermany

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