, Volume 15, Issue 2–3, pp 227–234 | Cite as

Cystathionine in the brains of tree shrews and other mammals

  • O. Elliot
  • N. A. Holtzman
  • V. A. McKusick


The amino acid cystathionine is reported to show higher concentrations in the brains of man as compared to those of other species. Two-dimensional separation by electrophoresis-chromatography and densitometric analysis of amino acids showed that the brains of tree shrews had levels of cystathionine intermediate between those of man and other mammals such as tamarins, hedgehogs, and rats. Cystathionine may be involved in the circadian rhythms ofTupaiidae. In man a 10 fold variation in cerebral cystathionine is related to pathological conditions. Greater concentrations in white matter as compared to grey matter and other regional differences in brain tissue support the findings from inherited disorders that cystathionine plays an important role in the normal as well as the abnormal functioning of the brain.


White Matter Brain Tissue Grey Matter Pathological Condition Circadian Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Japan Monkey Centre 1974

Authors and Affiliations

  • O. Elliot
    • 1
  • N. A. Holtzman
    • 2
  • V. A. McKusick
    • 3
  1. 1.Division of Clinical Nutrition-HGSThe Children's Hospital Medical CenterBostonUSA
  2. 2.Department of PediatricsThe Johns Hopkins HospitalUSA
  3. 3.The Moore ClinicThe Johns Hopkins HospitalBaltimoreUSA

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