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Immunogenicity of cell extract proteins in pulmonary nocardiosis

  • V. Punj
  • M. S. Kalra
  • P. N. Dwivedi
  • K. S. Singh
Research Papers
  • 28 Downloads

Summary

Crude protein fraction (CPF) ofNocardia asteroides was fractionated into F1 and F2 subfractions. CPF F1 elicited both cellular as well as humoral immune responses, while F2 was found to be non-immunogenic. Mice immunized with CPF F1 and challenged with calculated LD50 dose ofN. asteroides exhibited significant protection against nocardiosis as compared to non-immunized mice. CPF was found to be the best immunogen.

Keywords

Immune Response Extract Protein Cell Extract Crude Protein Protein Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Immunogénicité de protéines d'extrait cellulaire dans la nocardiose pulmonaire

Résumé

La fraction brute de protéines (CPF) deNocardia asteroides a été fractionnée en sous-fractions F1 et F2. CPF-F1 engendre les réponses immunologiques tant cellulaire qu'humorale, tandis que CPF-F2 s'est révélée non-immunologique. Des souris immunisées par CPF-F1 et soumises à des doses calculées pour un LD50 deN. asteroides ont montré une protection significative contre la nocardiose par comparaison aux souris non immunisées. CPF s'est révélé être le meilleur immunogène.

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References

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Copyright information

© Oxford University Press 1989

Authors and Affiliations

  • V. Punj
    • 1
  • M. S. Kalra
    • 1
  • P. N. Dwivedi
    • 1
  • K. S. Singh
    • 1
  1. 1.Department of Microbiology, College of Basic Sciences & HumanitiesPunjab Agricultural UniversityLudhianaIndia

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