Potential role of engineered microbes to de-toxify chemical pollutants

  • S. Balajee
  • A. Mahadevan


Microorganisms dissimilate a variety of organic substances. However, a few are recalcitrant to microbial attack. To degrade these substances, the biochemical activities of microorganisms need to be amplified either by increasing the activities of the existing pathways or evolving new degradative pathways. Genetic engineering offers tremendous scope in constructing powerful strains with enhanced dissimilating potential, multiple dissimilatory trait, to evolve hybrid pathways and in stabilising the degradative trait. Barrier to the successful application of the genetically-manipulated strains is anticipated in their environmental application. The prospects of using genetically-engineered strains to control pollution are emphasized.


Microbe Potential Role Organic Substance Genetic Engineering Environmental Application 
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Rôle potentiel de microorganismes manipulés génétiquement pour détoxifier les polluants chimiques


Les microorganismes catabolisent une variété de substances organiques. Toutefois un petit nombre de ces dernières sont récalcitrantes à l'attaque microbienne. Pour dégrader ces substances, les capacités biochimiques des microorganismes doivent être amplifiées soit en augmentant les activités de chemins métaboliques existants soit en créant de nouveaux chemins cataboliques. L'ingéniérie offre un large éventail de construction de souches puissantes avec un potentiel catabolique accru ou une aptitude catabolique multiple pour créer des chemins métaboliques hybrides et stabiliser l'aptitude catabolique. On pressent une barrière dans l'appliction couronnée de succès des souches manipulées génétiquement dans l'environnement. On met en évidence les perspectives de l'emploi de souches manipulées génétiquement pour contrôler la pollution.


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Copyright information

© Oxford University Press 1989

Authors and Affiliations

  • S. Balajee
    • 1
  • A. Mahadevan
    • 1
  1. 1.Centre for Advanced Study in BotanyUniversity of MadrasMadrasIndia

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