Cancer Immunology, Immunotherapy

, Volume 33, Issue 6, pp 421–423 | Cite as

Effect of advanced aging on ability of mice to cause regression of an immunogenic lymphoma in response to immunotherapy based on depletion of suppressor T cells

  • Pamela L. Dunn
  • Robert J. North
Short communication


This study shows that two therapeutic agents, anti-CD4 mAb and vinblastine, capable of causing T-cellmediated regression of an established L5178Y lymphoma in 3-month-old mice, are incapable of causing regression of this tumor in 20- to 22-month-old mice. It is known that both agents are immunoaugmentative because of their ability to destroy tumor-induced CD4+ suppressor T cells preferentially. Therefore, the results indicate, that aged mice, unlike young mice, are not capable of generating therapeutic numbers of CD8+ effector T cells in the absence of suppressor cells.

Key words

Aging Immunotherapy T-cell mediated Lymphoma 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Pamela L. Dunn
    • 1
  • Robert J. North
    • 1
  1. 1.The Trudeau InstituteSaranac LakeUSA

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