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Impaired neutrophil function in the cutaneous form of anthrax

Gestörte Neutrophilenfunktionen bei kutanem Anthrax

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Summary

Spontaneous andBacillus anthracis induced luminol-dependent chemiluminescence of neutrophils was studied in six patients with the cutaneous form of anthrax. Spontaneous chemiluminescence in anthrax was decreased compared to the healthy controls (p<0.05).B. anthracis, opsonized by complement-containing sera from patients, induced chemiluminescence in neutrophils from control donors but not from patients.B. anthracis, opsonized by complement-free sera from the patients, did not cause an increase in chemiluminescence response in either the patient or the control neutrophils. Also,B. anthracis, opsonized with normal sera and nonopsonized, did not induce chemiluminescence in either patient or control neutrophils. It was concluded that oxidative metabolism by neutrophils is impaired in anthrax, whereas the functional capacity of antibodies seems to be unaffected.

Zusammenfassung

Spontane und durchBacillus anthracis induzierte, luminolabhängige Chemilumineszenz der neutrophilen Granulozyten wurde bei sechs Patienten mit kutanem Anthrax untersucht. Im Vergleich zu Granulozyten von gesunden Kontrollpersonen wiesen die Zellen der Patienten eine verminderte spontane Chemilumineszenz auf (p<0,05). Opsonisierung derB. anthracis mit komplementhaltigem Serum der Patienten führte bei den Granulozyten der Kontrollpersonen, aber nicht bei den Patienten zur Chemilumineszenz-Induktion. Opsonierung mit komplementfreiem Serum induzierte weder Patienten- noch Kontroll-Granulozyten. Nach Opsonierung mit normalem Serum oder ohne Opsonierung konnteB. anthracis ebenfalls bei keiner der Neutrophilengruppe eine erhöhte Chemilumineszenzreaktion hervorrufen. Aus den Daten wird auf einen defekten Sauerstoffmetabolismus der neutrophilen Granulozyten bei Anthrax geschlossen, die funktionelle Kapazität der Antikörper scheint hingegen nicht gestört zu sein.

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Authors and Affiliations

  1. Dept. of Infectious Diseases, Clinics of the Medical University, 443021, Samara

    O. A. Alexeyev M. D., V. G. Morozov M. D. & A. S. Mishukov M. D.

  2. Div. of Clinical Immunology, Samara State Medical University, 443099, Samara

    T. V. Suzdaltseva M. D.

  3. Dept. of Bacteriology, Regional Epidemiological Station, Div. of Emerging Infections, Samara, Russia

    L. A. Steinberg M. D.

Authors
  1. O. A. Alexeyev M. D.
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  2. V. G. Morozov M. D.
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  3. T. V. Suzdaltseva M. D.
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  4. A. S. Mishukov M. D.
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  5. L. A. Steinberg M. D.
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Alexeyev, O.A., Morozov, V.G., Suzdaltseva, T.V. et al. Impaired neutrophil function in the cutaneous form of anthrax. Infection 22, 281–282 (1994). https://doi.org/10.1007/BF01739917

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  • DOI: https://doi.org/10.1007/BF01739917

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