, Volume 21, Issue 1, pp 49–53 | Cite as

Timing, dosing and duration of antimicrobial prophylaxis in urology: A study in guinea pigs with special reference to high-risk conditions

  • T. C. Gasser
  • P. O. Madsen


A study in guinea pigs was performed to investigate the importance of timing, dosage and duration of antimicrobial prophylaxis in urologic surgery. To simulate high-risk conditions, in one group a foreign body was implanted subcutaneously. The prostate and one kidney were cauterized and bacteremia was induced by intravenous injection of anEscherichia coli suspension. Various ciprofloxacin regimens were tested. The results indicate that antimicrobial prophylaxis is beneficial only if administered before or shortly after surgery. Full therapeutic dosage may not be necessary for prophylactic efficacy. Single-dose prophylaxis was as effective as multiple doses. Foreign body infection could be prevented by single-dose prophylaxis.


Foreign Body Therapeutic Dosage Multiple Dose Antimicrobial Prophylaxis Prophylactic Efficacy 
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Zeitpunkt, Dosierung und Dauer antimikrobieller Prophylaxe in der Urologie: Studien am Meerschweinchen zu Hochrisiko-Eingriffen


Um die Bedeutung von Zeitpunkt, Dosierung, und Dauer antimikrobieller Prophylaxe in der urologischen Chirurgie zu untersuchen, wurde eine experimentelle Studie an Meerschweinchen durchgeführt. Einer Gruppe von Tieren wurde vier Wochen vor den Experimenten ein subkutaner Fremdkörper implantiert. Sie diente als Riskikogruppe. Die Prostata und eine Niere wurden elektrokoaguliert. Durch intravenöse Injektion einerEscherichia coli-Suspension wurde eine Bakteriämie erzeugt. Ciprofloxacin wurde zu verschiedenen Zeitpunkten, in verschiedenen Dosierungen und unterschiedlich lange verabreicht. Antimikrobielle Prophylaxe war wirksam, wenn sie kurz vor oder nach den Bakterien verabreicht wurde. Ein Teil der normalen therapeutischen Dosis scheint für eine wirkungsvolle Prophylaxe auszureichen. Die Einmaldosierung war ebenso wirksam wie die Mehrfachdosierung. Die Fremdkörperinfektion konnte durch eine einzelne Dosis zuverlässig verhindert werden.


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Copyright information

© MMV Medizin Verlag GmbH München 1993

Authors and Affiliations

  • T. C. Gasser
    • 1
  • P. O. Madsen
    • 2
  1. 1.Urologische Klinik, Kantonsspital BaselBaselSwitzerland
  2. 2.VA HospitalMadisonUSA

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