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AT III in septicemia with DIC

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Abstract

In the development of sepsis DIC is a common complication. Several studies presented in this paper show a coincidence between the development of DIC and depletion of Antithrombin III, a serine protease inhibitor which inhibits a large scale of activated clotting factors. It seems very probable that substitution therapy should be of benefit in the treatment of sepsis-related DIC and may improve the outcome of septic patients. Physiological and clinical findings are put together to clarify the basic rationale for running clinical trials and future studies.

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  1. Medizinische Klinik I, Städtisches Krankenhaus Hildesheim, Weinberg 1, D-31134, Hildesheim, Germany

    H. -P. Schuster

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  1. H. -P. Schuster
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Schuster, H.P. AT III in septicemia with DIC. Intensive Care Med 19 (Suppl 1), S16–S18 (1993). https://doi.org/10.1007/BF01738945

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