Skip to main content
SpringerLink
Log in

Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

The case of a patient with erythrocyte pyruvate kinase (PK) deficiency hemolytic anemia leading to extramedullary hematopoiesis in a paravertebral myelolipoma is presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Blume KG, Arnold H, Löhr GW (1974) Hereditäre Enzymdefekte des Erythrozyten: Expressivität und molekulare Heterogenität anomaler Enzymproteine. Ergeb Inn Med Kinderheilkd 35:43–66

    Google Scholar 

  2. Brannan D (1927) Extramedullary hematopoiesis in anemias. Bull Johns Hopkins Hosp 41:104–135

    Google Scholar 

  3. Close AS, Taira Y, Cleveland DA (1958) Spinal cord compression due to extramedullary hematopoiesis. Ann Int Med 48:421–427

    Google Scholar 

  4. Covey GW (1935) Erythroblastosis: report of case presenting erythroblastic tumor in thoracic cavity. Am J Pathol 11:551–560

    Google Scholar 

  5. Dawson BE (1931) Hume lectures on haemolytic icterus. Br Med J 1:963–966

    Google Scholar 

  6. Donhauser JL (1908) Human spleen as haematoplastic organ exemplified in case of splenomegaly with sclerosis of bone marrow. J Exp Med 10:559–574

    Google Scholar 

  7. Drake CT, Marshall LW, Meyers SN, Shilds TW (1965) Ectopic hematopoietic tissue masquerading as mediastinal tumor. Ann Thorac Cardiovasc Surg 1:742–745

    Google Scholar 

  8. Forster JBT (1958) Primary thoracic myelolipoma: case report. AMA Arch Pathol 65:295–297

    Google Scholar 

  9. Giffen HK (1947) Myelolipoma of adrenals: report of 7 cases. Am J Pathol 23:613–625

    Google Scholar 

  10. Hanford RB, Schneider GF, MacCarthy JD (1960) Massive thoracic extramedullary hematopoiesis. N Engl J Med 263:120–123

    Google Scholar 

  11. Hartfall SJ, Stewart MJ (1933) Massive paravertebral heterotopia of bone marrow in case of acholuric jaundice. J Pathol Bacteriol 37:455–459

    Google Scholar 

  12. Jordan HE (1942) Extramedullary blood production. Physiol Rev 22:375–385

    Google Scholar 

  13. Jordan HE (1934) Extramedullary erythrocytopoiesis in man. Arch Pathol 18:1–21

    Google Scholar 

  14. Kahn A, Marie J, Galand C, Boivin P (1976) Chronic hemolytic anaemia in two patients heterozygous for erythrocyte pyruvate kinase deficiency. Scand J Haematol 16:250–257

    Google Scholar 

  15. Knoblich R (1960) Extramedullary hematopoiesis presenting intrathoracic tumor: report of case in patient with thalassemia minor. Cancer 13:462–468

    Google Scholar 

  16. Litwer H (1960) Myelolipoma of mediastinum. Radiology 74:471–473

    Google Scholar 

  17. Lowman RM, Bloor CM, Newcomb AW (1963) Roentgen manifestations of thoracic extramedullary hematopoiesis. Dis Chest 44:154–162

    Google Scholar 

  18. Lyall A (1935) Massive extramedullary bone-marrow formation in a case of pernicious anaemia. J Pathol Bacteriol 41:469

    Google Scholar 

  19. Marinozzi V (1958) Aspetti insoliti dell'iperplasia midollare nelle anemia emolitiche. Haematologica 43:737–759

    Google Scholar 

  20. Miwa S (1981) Pyruvate kinase deficiency and other enzymopathies of the Embden-Meyerhof pathway. Clin Haematol 10:57–80

    Google Scholar 

  21. Miwa S, Nishina T (1974) Studies on pyruvate kinase deficiency. I. Clinical, hematological and erythrocyte enzyme studies. Acta Haematol Jap 37:1–16

    Google Scholar 

  22. Parsons L Jr, Thompson JE (1959) Symptomatic myelolipoma of the adrenal gland. Report of a case and review of the literature. N Engl J Med 260:12

    Google Scholar 

  23. Plonskier M (1930) Über tumorförmige (extramedulläre, heterotope) subpleurale Knockenmarksherde. Virchows Arch [Pathol Anat] 277:804–809

    Google Scholar 

  24. Ross P, Logan W (1969) Roentgen findings in extramedullary hematopoiesis. Am J Radiol 106:604–613

    Google Scholar 

  25. Saleeby ER (1925) Heterotopia of bone marrow without apparent cause. Am J Pathol 1:69–76

    Google Scholar 

  26. Schiller W (1943) Local myelopoiesis in myeloid leukemia. Am J Pathol 19:809–837

    Google Scholar 

  27. Seidler RC, Becker JA (1964) Intrathoracic extramedullary hematopoiesis. Radiology 83:1057–1059

    Google Scholar 

  28. Tanaka KR, Paglia DE (1971) Pyruvate kinase deficiency. Semin Hematol 8:367–396

    Google Scholar 

  29. Wintrobe MM (1981) Clinical hematology, 8th edn. Lea & Febiger, Philadelphia

    Google Scholar 

  30. Wintrobe MM (1936) Relation of disease of liver to anemia: type of anemia, response to treatment, and relation of type of anemia to histopathologic changes in liver, spleen and bone marrow. Arch Int Med 57:289–306

    Google Scholar 

  31. Young JK, Cooperman MB (1922) Von Recklinghausen's disease or osteitis fibrosa: with report of case presenting multiple cysts and giant-cell tumors. Ann Surg 75:171–180

    Google Scholar 

  32. Zuelzer WE, Robinson AR, Hsu THH (1968) Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers? Blood 32:33–48

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology and Oncology, I. Med. Clinic, Technical University of Munich, Germany

    H. R. Schön, B. Emmerich, P. A. Maubach & J. Rastetter

  2. Department of Hematology, University of Freiburg, Germany

    H. Arnold

  3. Institute of Pathology, Technical University of Munich, Germany

    K. Becker

Authors
  1. H. R. Schön
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Emmerich
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Arnold
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. A. Maubach
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Becker
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Rastetter
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to Professor Dr. med. Hans Blömer on the occasion of his 60th birthday

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schön, H.R., Emmerich, B., Arnold, H. et al. Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma. Klin Wochenschr 62, 133–137 (1984). https://doi.org/10.1007/BF01738704

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01738704

Key words

Search

Navigation