Summary
An open trial with thiamine tetrahydrofurfuryl disulphide (TTFD) was carried out on 44 patients with nutritional polyneuropathy who were admitted to the Neurological Department, Dr. Soetomo Hospital, Surabaya, Indonesia, Thirty-four patients showed improvement of their motor functions (P < 0.01) with slight restoration of sensory function and reflexes (P < 0.1). Of the 18 patients who were re-examined electrophysiologically 3 months later, 6 showed remarkable improvements. No sideeffects were observed during TTFD treatment. It seemed that nutritional polyneuropathy in our low socio-economic patients was mostly caused by thiamine deficiency.
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Djoenaidi, W., Notermans, S.L.H. Thiamine tetraphydrofurfuryl disulfide in nutritional polyneuropathy. Eur Arch Psychiatr Neurol Sci 239, 218–220 (1990). https://doi.org/10.1007/BF01738575
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DOI: https://doi.org/10.1007/BF01738575