Annals of Hematology

, Volume 66, Issue 5, pp 247–249 | Cite as

MCNU in the treatment of essential thrombocythemia — a pilot study

  • H. Murakami
  • J. Tamura
  • M. Sawamura
Original Article


The efficacy of a single dose of MCNU 150 mg was evaluated in nine symptomatic patients with essential thrombocythemia (ET). As the platelet counts increased during the following 4 weeks, an extra dose of 100 mg of MCNU was administered to three patients. All patients had thrombotic or hemorrhagic complications. Seven patients responded. The mean platelet count decreased to below 1.0×1012/l within 5 weeks; it reached its lowest level (0.35×1012/l) at 6 weeks and became stable at less than 1.0×1012/l without further therapy for 12 weeks in all patients. Thrombotic and hemorrhagic complications ameliorated within 4 weeks in all patients. Our study indicates that MCNU acts as a platelet-reducing agent in patients with ET.

Key words

MCNU Essential thrombocythemia Platelet 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • H. Murakami
    • 1
  • J. Tamura
    • 1
  • M. Sawamura
    • 1
  1. 1.Third Department of Internal MedicineGunma University School of MedicineGunmaJapan

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