Summary
The case of a 57-year-old patient with a plasmablastic lymphoma is described. The primary diagnosis was an ordinary plasmacytoma, type IgG kappa. The final course of the disease involved almost all of the organs. The clinical aspect was determined by multiple skin infiltrations. The present report has in common with other published cases the fact that multiple secondary skin involvement of immunoglobulin-secreting tumors, regardless of their origin, have a very poor prognosis. In comparison, primary multiple cutaneous immunoglobulin-secreting tumors have a better prognosis.
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Abbreviations
- AntiHBc:
-
Anti-hepatitis B core
- AntiHBe:
-
Anti-hepatitis B early antigen
- BUN:
-
Blood urea nitrogen
- DNA:
-
Desoxyribonucleid acid
- HBsAG:
-
Hepatitis B surface antigen
- IgA:
-
Immunoglobulin A
- IgG:
-
Immunoglobulin G
- IgM:
-
Immunoglobulin M
- IST:
-
Immunoglobulin-secreting skin tumors
- LDH:
-
Lactate dehydrogenase
- SGOT:
-
Serum glutamic oxaloacetic transaminase
- SGPT:
-
Serum glutamic pyruvic transaminase
- WBC:
-
White blood cell
References
Alberts DS, Lynch P (1978) Cutaneous plasmacytomas in myeloma. Arch Dermatol 114:1784–1787
Bataille R, Durie BGM, Grenier J, Sany J (1986) Prognostic factors and staging in multiple myeloma: a reappraisel. J Clin Oncol 4:80–87
Beevers DG (1972) Cutaneous lesions in multiple myeloma. Br Med J 4:275–276
Bluefarb SM (1955) Cutaneous manifestation of multiple myeloma. Arch Dermatol 72:506–523
Bork K, Weigand U (1975) Multiple Plasmocytome der Haut mit IgA-Vermehrung im Serum ohne Knochenmarkbeteiligung. Arch Derm Res 254:245–252
Braun-Falco O, Burg G (1983) Maligne Lymphome der Haut. Internist 24:306–320
Burke WA, Meritt CC, Briggaman RA (1986) Disseminated extramedullary plasmacytomas. J Am Acad Dermatol 14:335–339
Canlas MS, Dillon ML, Loughrin JJ (1979) Primary cutaneous plasmacytoma. Arch Dermatol 115:722–724
Cavo M, Gobbi M, Ghetti P, Patrizi A, Pileri S, Varotti C (1983) Secondary cutaneous plasmacytoma. Acta Haemat 69:287–288
Durie BGM, Salmon SE (1975) A clinical staging system for multiple myeloma. Cancer 36:842–854
Fayol J, Bernhard P, Bordessoule D, Vire O, Malinvaud G, Bonnetblanc JM (1985) Localisations cutanées specifiques au cours du myelome multiple et de la macroglobulinemie de Waldenström; à propos de 4 observations. Ann Dermatol Venereol 112:509–516
Gomez EC, Margulies M, Rywlin A, Cabello B, Dominguez C (1978) Cutaneous involvement by IgD myeloma. Arch Dermatol 114:1700–1703
Hauke G, Epplen JT, Hinkkanen A, Köchling G, Peter HH (1988) Malignes plasmoblastisches Lymphom mit monoklonalem IgG-kappa-Immunglobulin und nachweisbaren Immunglobulin-C-delta-Genen. Med Klin 83:246–250
Hayes DW, Benett WA, Heck FJ (1952) Extramedullary lesions in multiple myeloma; review of literature and pathologic studies. Arch Pathol 53:262–272
Horiuchi Y, Ohbu M, Kanzaki T (1985) Multiple cutaneous plasmacytomas observed in IgD myeloma. J Dermatol (Tokyo) 12:277–279
Kerl H, Burg G (1979) Immunozytome und immunoblastische Lymphome der Haut. Hautarzt 30:666–672
Kerl H, Burg G (1984) Histomorphology and cytomorphology of cutaneous B-cell lymphomas. J Dermatol Surg Oncol 10:266–270
Kövary PM, Macher E (1979) Hautkrankheiten und monoklonale Gammopathien. Z Hautkr 54:1002–1007
LaPerriere RJ, Wolf JE, Gellin GA (1973) Primary cutaneous plasmacytoma. Arch Dermatol 107:99–100
Levin HA, Freeman RG, Smith FE, Lane M (1967) Multiple extramedullary plasmacytomas. Arch Dermatol 96:456–461
Lynch PJ (1979) Cutaneous lesions in multiple myeloma. In: Helm F (ed) Cancer dermatology. Lea and Febiger, Philadelphia, pp 229–233
Merk H, Goerz G (1984) Hautveränderungen bei Paraproteinämien (monoklonale Gammopathien). Hautarzt 35:126–131
Mikhail GR, Spindler AC, Kelly AP (1970) Malignant plasmacytoma cutis. Arch Dermatol 101:59–62
Nakamura S, Hoshi K, Onda S, Kamiya S (1984) Primary cutaneous IgA plasmacytoma. J Dermatol (Tokyo) 11:482–486
Piette WW (1986) Myeloma, paraproteinemias, and the skin. Med Clinics North Am 70:155–176
River GL, Schorr WF (1966) Malignant skin tumors in multiple myeloma. Arch Dermatol 93:432–438
Rodriguez JM, Lam S, Silber R (1977) Multiple myeloma with cutaneous involvement. JAMA 237:2625–2626
Shah A, Klimo P, Worth A (1982) Multiple myeloma first observed as multiple cutaneous plasmacytomas. Arch Dermatol 118:922–924
Stankler L, Davidson JF (1974) Multiple extra-medullary plasmacytomas of the skin. Br J Dermatol 90:217–221
VanderPutte SCJ, Go DMDS, DeKreek EJ, VanUnnik JAM (1984) Primary cutaneous lymphoplasmacytoid lymphoma (immunocytoma). Am J Dermatol 6:15–24
Walzer RA, Shapiro L (1967) Multiple myeloma with cutaneous involvement. Dermatologica 134:449–454
Wiltshaw E (1976) The natural history of extramedullary plasmacytomas and its relation to solitary myeloma of the bone and myelomatosis. Medicine 55:217–238
Wuepper KD, MacKenzie MR (1969) Cutaneous extramedullary plasmacytomas. Arch Dermatol 100:155–164
Zurborn KH, Sondermann I, Gross WL (1985) Abnahme der Paraproteinsekretion trotz progredienter Tumorzellproliferation unter Zytostaticatherapie eines Plasmozytoms. Internist 26:584–586
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Dedicated to Prof. Dr.Dr. G.W. Löhr on the occasion of his 65th birthday in July 1987
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Köchling, G., Ochs, A., Hauke, G. et al. Plasmablastic immunoglobulin-secreting lymphoma. Klin Wochenschr 66, 990–994 (1988). https://doi.org/10.1007/BF01738115
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DOI: https://doi.org/10.1007/BF01738115