Abstract
The aim of the study was to evaluate the possibility of detecting thyroid cancer recurrences without the need for withdrawal of thyroid suppressive treatment. Upper-body or whole-body scintigraphy was performed in a group of 200 patients evaluated for differentiated thyroid cancers in 1993 and 1994 using technetium-99m sestamibi. Scans were performed 20–30 min following i.v. administration of 500 MBq of99mTc-methoxyisobutylisonitrile (MIBI). Bone and lung metastases were detected with very high sensitivity and specificity, with a very high predictive value of negative results and a somewhat lower predictive value of positive results. The sensitivity and specificity of findings in the neck were lower but the predictive value of negative results was high. Whole-body scans with99mTc-MIBI are a useful tool in the follow-up of patients with differentiated thyroid cancer, for the detection of distant metastatic lesions.
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References
Němec J, Rohling S, Zamrazil V, Pohunková D. Comparison of the distribution of diagnostic and thyroablative131I in the evaluation of differentiated thyroid cancers.J Nucl Med 1979; 20: 92–97.
Němec J, Nývltová O, Preiningerová M, et al. Positive thyroid cancer scintigraphy using technetium-99m tetrofosmin (Myoview).Nucl Med Commun 1995; 16; 694–697.
Kao CH, Wang SJ, Liao SQ, et al. Quick diagnosis of hyperthyroidism with semiquantitative 30-min technetium-99m-methoxy-isobutyl-isonitrile thyroid uptake.J Nucl Med 1993; 34: 71–74.
Maurea S, Lastoria S, Klain M, et al. Technetium-99m MIBI scans in the initial evaluation and post-surgical follow-up of thyroid cancer.J Nucl Med 1994; 35: 166P.
Vattimo A, Bertelli P, Burroni L. Effective visualization of suppressed thyroid tissue by means of baseline99mTc-methoxy isobutyl isonitrile in comparison with99mTc-pertechnetate scintigraphy after TSH stimulation.J Nucl Biol Med 1992; 36: 315–318.
Hamann A, Kotzerke J, Gratz KF, et al. Comparison of Tc-99m-MIBI and Tl-201 in the follow-up of oxyphilic thyroid carcinomas (OTC).Eur J Nucl Med 1994; 21: 866.
Briele B, Hotze A, Kropp J, et al. Comparison of 201 Tl and 99mTc-MIBI in the follow-up of differentiated thyroid carcinomas.Nuklearmedizin 1991; 30: 115–124.
Yen TC, Lin HD, Lee CH et al. The role of technetium-99m sestamibi whole-body scans in diagnosing metastatic Hürthle cell carcinoma of the thyroid gland after total thyroidectomy: comparison with iodine-131 and thallium-201 whole body scans.Eur J Nucl Med 1994; 21:980–983.
Sundram FX, Goh AS, Ang ES. Role of technetium-99m sestamibi in localisation of thyroid cancer metastases.Ann Acad Med Signapore 1993; 22: 557–559.
Moriya E, Shirakawa T, Moriya E, Mori Y, et al. Efficacy of Tc-99m-MIBI SPECT in seeking metastatic lesions of thyroid cancer [abstract].J Nucl Med 1994; 35: 226P–227P.
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Němec, J., Nývltová, O., Blažek, T. et al. Positive thyroid cancer scintigraphy using technetium-99m methoxyisobutylisonitrile. Eur J Nucl Med 23, 69–71 (1996). https://doi.org/10.1007/BF01736992
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DOI: https://doi.org/10.1007/BF01736992