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Der Einfluß von Diazoxid auf die Glueagon-induzierte Insulinsekretion

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Zusammenfassung

In tierexperimentellen Untersuchungen an adrenalektomierten Ratten wurde der Einfluß von Glucagon (0,1 mg/kg) auf die Insulinsekretion und den Blutzucker nach Vorbehandlung mit 200 mg/kg Diazoxid untersucht. Bei normal gefütterten Tieren war die glucagoninduzierte Insulinsekretion nach Diazoxid stark vermindert, aber nicht völlig aufgehoben. Nach 24stündigem Fasten hatte Diazoxid keine hemmende Wirkung auf die glucagonstimulierte Insulinsekretion.

Summary

The influence of diazoxide on glucagon-stimulated insulin secretion has been studied using adrenalectomized rats. 200 mg/kg of diazoxide were injected intraperitoneally 2 hours prior to the experiments, and the animals killed by decapitation 1 or 5 minutes after intravenous injection of 0.1 mg/kg of glucagon. In animals fed ad libitum diazoxide considerably decreased insulin secretion stimulated by glucagon. After fasting for 24 hours, however, diazoxide showed no effect whatsoever on glucagon-stimulated insulin secretion. It has been concluded that the mode of action of glucagon on insulin secretion is different from that of glucose that has been shown to be blocked by diazoxide.

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Authors and Affiliations

  1. Medizinische Universitätsklinik (Ludolf Krehl-Klinik) Heidelberg, Germany

    W. J. Brech, H. Kaess, G. Schlierf & M. Rohs

Authors
  1. W. J. Brech
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  2. H. Kaess
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  3. G. Schlierf
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  4. M. Rohs
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Der Deutschen Forschungsgemeinschaft sei für die Unterstützung unserer Untersuchungen gedankt.

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Brech, W.J., Kaess, H., Schlierf, G. et al. Der Einfluß von Diazoxid auf die Glueagon-induzierte Insulinsekretion. Klin Wochenschr 46, 449–450 (1968). https://doi.org/10.1007/BF01736940

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  • DOI: https://doi.org/10.1007/BF01736940

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