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Basic fibroblast growth factor and its relation to angiogenesis in normal and neoplastic tissue

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Summary

Basic fibroblast growth factor is a protein widely distributed in the organism. It can stimulate the proliferation and differentiation of many cells and it is extremely potent in inducing angiogenesis, the formation of new blood vessels. In this article, some of its structural and biological properties are reviewed. In particular, the possible implications of basis fibroblast growth factor in normal and tumor angiogenesis are considered.

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Abbreviations

bFGF:

basic fibroblast growth factor

kb:

kilobases

Mr:

relative molecular weight

pI:

isoelectric point

TAF:

tumor angiogenesis factor

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Authors and Affiliations

  1. Abteilung für Klassische und Molekulare Genetik, Universitäts-Kinderklinik und Deutsches Krebsforschungszentrum, Heidelberg

    L. Schweigerer

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  1. L. Schweigerer
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Schweigerer, L. Basic fibroblast growth factor and its relation to angiogenesis in normal and neoplastic tissue. Klin Wochenschr 66, 340–345 (1988). https://doi.org/10.1007/BF01735791

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  • DOI: https://doi.org/10.1007/BF01735791

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