Literatur
Camsonne R: Endogenous benzodiazepines in brain: right or wrong? (1988) Trends Neurosci 11:100
Haefely W (1988) Endogenous ligands of the benzodiazepine receptor. Pharmacopsychiat 21:43–46
Klotz U (1985) Tranquillantien-therapeutischer Einsatz und Pharmakologie. Wissenschaftl. Verlagsges., Stuttgart
Möhler H, Okada (1977) Benzodiazepine receptor demonstration in the central nervous system. Science 198:849–851
Sangameswaran L, Fales HM, Friedrich P, de Blas AL (1986) Purification of a benzodiazepine from bovine brain and detection of benzodiazepine — like immunoreactivity in human brain. Proc Natl Acad Sci USA 83:9236–9240
Schofield PR, Darlison MG, Fujita N, Burt DR, Stephenson FA, Rodriguez H, Rhee LM, Ramachandran J, Reale V, Glencorse TA, Seeburg PH, Barnard EA (1987) Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor superfamily. Nature 328:221–227
Squires RF, Braestrup C (1977) Benzodiazepine receptors in the rat brain. Nature 266:732–734
Sternbach LH (1979) The benzodiazepine story. J Med Chem 22:1–7
Unseld E, Krishna DR, Fischer C, Klotz U (1989) Detection of desmethyldiazepam and diazepam in brain of different species and plants. Biochem Pharmacol (submitted)
Gerlach M, Schwelle N, Lerbs W, Luckner M (1985) Enzymatic synthesis of cyclopeptine intermediates in penicillium cyclopium. Phytochem 24:1935–1939
Weitz CJ, Lowney LI, Faull KF, Feistner G, Goldstein A (1986) Morphine and codeine from mammalian brain. Proc Natl Acad Sci USA 83:9784–9788
Weitz CJ, Faull KF, Goldstein A (1987) Synthesis of the skeleton of the morphine molecule by mamalian liver. Nature 330:674–677
Wildmann J, Möhler H, Vetter W, Ranalder U, Schmidt K, Maurer R (1987) Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin. J Neural Transm 70:383–398
Wildmann J, Vetter W, Ranalder UB, Schmidt K, Maurer R, Möhler H (1988) Occurence of pharmacologically active bencodiazepines in trace amounts in weath and potato. Biochem Pharmacol 37:3549–3559
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Klotz, U. Stellen Benzodiazepine „natürliche“ Arzneimittel dar?. Klin Wochenschr 67, 93–94 (1989). https://doi.org/10.1007/BF01735658
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DOI: https://doi.org/10.1007/BF01735658