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Klinische Wochenschrift

, Volume 65, Issue 23, pp 1139–1141 | Cite as

Altered ribosomal protein synthesis in congenital non-progressive myopathy

  • H. Pöche
  • E. Kattner
Originalien

Summary

Ribosomes isolated from fibroblasts, muscle tissues, and blood cells of a patient with congenital non-progressive myopathy were used for in vitro measurement of protein synthesis in a heterologous poly(U)-directed polyphenylalanine synthesis system. The activity of ribosomes obtained from the patient was 35% lower than that in normal controls.

Key words

Congenital non-progressive myopathy Protein synthesis Ribosomes 

Abbreviations

CK

Creatine kinase

Mb

Myoglobin

LDH

Lactate dehydrogenase

poly(Phe) synthesis

Poly(U)-directed polyphenylalanine synthesis

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • H. Pöche
    • 1
  • E. Kattner
    • 2
  1. 1.Neurologische KlinikUniversitätsklinikum Steglitz, Freie Universität BerlinGermany
  2. 2.Universitätskinderklinik (Kaiserin Auguste Viktoria Haus), Freie Universität BerlinGermany

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