Skip to main content
SpringerLink
Log in

Beeinflussung der Vorphase der Gerinnung durch Dextran 150 in vitro

  • Kurze Wissenschaftliche Mitteilungen
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Zusammenfassung

Thromboplastinbildung im Plasma konnte nach Zugabe von Dextran 150 in vitro nachgewiesen werden. Die angewandte Modifikation des Thromboplastinbildungstestes macht es wahrscheinlich, daß die Beschleunigung des Gerinnungsvorganges über die Bildung des Kontaktproduktes (Faktor XII und XI) eingeleitet wird.

Summary

There is evidence of formation of thromboplastin in human plasma in vitro after adding Dextran 150. By the modification of the TBT it can be assumped that the acceleration of the coagulation process is induced via a contact product (Activated factor XI and XII).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  • Astrup, T., andP. Ollendorf: Estimation of thromboplastin activation in plasma. Scand. J. clin. Lab. Invest.13, 377 (1961).

    Google Scholar 

  • Bergentz, S. E., O. Eiken, andI. M. Nilsson: The effect of dextran of various molecular weight on the coagulation in dogs. Thrombos. Diathes. haemorrh. (Stuttg.)6, 15 (1961).

    Google Scholar 

  • Deutsch, E.: Die Antikoagulantien in der Therapie der peripheren arteriellen Durchblutungsstörungen. Wien. klin. Wschr.76, 151 (1964).

    Google Scholar 

  • Egli, H., u.R. Klesper: Untersuchungen über den Thrombokinase-Bildungstest. Thrombos. Diathes. haemorrh. (Stuttg.)2, 39 (1961).

    Google Scholar 

  • Fischer, M., u.H. Wimmer: Aktivierung des fibrinolytischen Systems durch niedermolekulares Dextran. Vortrag geh. auf dem int. Transfusionskongr. Stockholm, 8. 9. 1964.

  • Gelin, L. E., K. Korsan-Bengtsen, J. Ygge, andB. Zederfeldt: Influence of low viscous dextran on the hemostatic mechanism. Acta chir. scand.122, 324 (1961).

    Google Scholar 

  • Herschlein, H. J., u.D. F. Steichele: Die Hemmung der Hyperkoagulabilität des Blutes. Med. Welt24, 1314 (1964).

    Google Scholar 

  • Lasch, H. G., H. J. Krecke, F. Rodriguez-Erdmann, H. H. Sessner u.G. Schütterle: Verbrauchskoagulopathien. (Pathogenese und Therapie). Fol. haemat. (Frankfurt) N.F.6, 325 (1961).

    Google Scholar 

  • Long jr., D. M.: Pharmacology of low molecular weight dextran and its effect on clotting and crossmatching. Conference on “Evaluation of low molecular weight dextran in shock”. Washington, 1963.

  • McFarlane, R. G.: An enzyme cascade in the blood clotting mechanism, and it function as a biochemical amplifier. Nature (Lond.)202, 495 (1964).

    Google Scholar 

  • Nilsson, I. M., andO. Eiken: Further studies on the effect of dextran of various molecular weight on the coagulation mechanism. Thrombos. Diathes. haemorrh. (Stuttg.)11, 38 (1964).

    Google Scholar 

  • Nossel, H. L.: The contact phase of blood coagulation. Oxford: Blackwell Sci. Publ. 1964.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Aus der Universitäts-Frauenklinik Heidelberg, Germany

    Walther Kuhn & Henner Graeff

Authors
  1. Walther Kuhn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Henner Graeff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuhn, W., Graeff, H. Beeinflussung der Vorphase der Gerinnung durch Dextran 150 in vitro. Klin Wochenschr 43, 1281–1282 (1965). https://doi.org/10.1007/BF01734706

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01734706

Search

Navigation