Journal of Molecular Evolution

, Volume 10, Issue 4, pp 339–348 | Cite as

Generalization and simplification of the Moore-Goodman test for significance of alignment homologies

  • Helmut Vogel
Article

Summary

A test given by Moore and Goodman (1977) that checks the significance of a homology between protein sequences is generalized to any type of distance measure and to any classification of codon pairs or amino acids according to this measure. A normal distribution is shown to approximate satisfactorily the probability distribution underlying this test for the examples chosen, and supposedly for any distance measure. The test accordingly reduces to a simple standard procedure.

Key words

Protein sequence alignments Evolutionary divergence Minimum mutation distance Homologous sequences Significance test Normal distribution 

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References

  1. Barker, W.C., Dayhoff, M.O. (1972). Atlas of Protein Sequence and Structure5, 103Google Scholar
  2. Dayhoff, M.O. (1972). Atlas of Protein Sequence and Structure5, D 13, D 56, D 315Google Scholar
  3. Moore, G.W., Goodman, M. (1977). J. Mol. Evol.9, 121–130Google Scholar
  4. Vogel, H., Bruschi, M., Le Gall, J. (1977). J. Mol. Evol.9, 111–119Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Helmut Vogel
    • 1
  1. 1.Département de Biochimie Macromolélaire, CNRSMontpellierFrance

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