Klinische Wochenschrift

, Volume 63, Issue 9, pp 423–427 | Cite as

Central nervous system involvement in hairy cell leukemia

  • H. Knecht
  • H. Budmiger
  • P. Groscurth
  • R. A. Streuli


A patient with central nervous system involvement by hairy cell leukemia is reported. Hairy cells were identified in the cerebrospinal fluid by electron microscopy and by tartrate-resistant acid phosphatase positive staining. Intrathecal treatment with methotrexate resulted in neurologic improvement, but was complicated by Cryptococcus neoformans meningitis. The leukemic phase of the disease was later successfully controlled by treatment with alpha interferon. Surface marker studies indicated a B- and T-cell phenotype of the hairy cells.

Key words

Hairy cell leukemia Central nervous system involvement Methotrexate Interferon 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • H. Knecht
    • 1
  • H. Budmiger
    • 1
  • P. Groscurth
    • 1
  • R. A. Streuli
    • 1
  1. 1.Department für Innere Medizin und Anatomisches Institut der Universität ZürichSchweiz

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