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Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis

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Summary

Fifty cases of idiopathic membranoproliferative glomerulonephritis were followed up for an average of 10±0.9 (SE) years. Forty of them, who presented a nephrotic syndrome, were treated by immunosuppressive drugs (prednisone, azathioprine, chlorambucil, cyclophosphamide) for 79±9.7 (SE) months. Cumulative survival ratio for 5, 10 and 15 years after enrolment was 0.90, 0.82 and 0.77 and after appearance of first symptoms or signs of kidney disease as determined by anamnestic data 0.97, 0.91 and 0.90 accordingly.

Triple-drug therapy (prednisone and azathioprine combined with chlorambucil or cyclophosphamide) was more effective in improving proteinuria than other immunosuppressive regimens. No serious side effects were encountered.

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Abbreviations

MPGN:

membranoproliferative glomerulonephritis

IgG:

immunoglobulin G

C3 :

complement C3

FU curve:

Follow-up curve

DD curve:

Disease duration curve

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Authors and Affiliations

  1. Transplantation Institute Warsaw School of Medicine, Warsaw, Poland

    T. Orlowski, Z. Rancewicz, M. Lao, J. Juskowa, J. Klepacka, L. Gradowska, W. Morzycka-Michalik & J. Glyda

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  1. T. Orlowski
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  2. Z. Rancewicz
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  3. M. Lao
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  4. J. Juskowa
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  5. J. Klepacka
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  6. L. Gradowska
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  7. W. Morzycka-Michalik
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  8. J. Glyda
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Additional information

Supported by Ministry of Health Grant, 10 MZ XIII

Nachtrag zu den Hauptreferaten des 19. Kongresses der Gesellschaft für Nephrologie in Göttingen (Klin Wochenschr 66/18)

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Orlowski, T., Rancewicz, Z., Lao, M. et al. Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis. Klin Wochenschr 66, 1019–1023 (1988). https://doi.org/10.1007/BF01733447

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  • DOI: https://doi.org/10.1007/BF01733447

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