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Klinische Wochenschrift

, Volume 63, Issue 12, pp 572–574 | Cite as

Pharmacokinetic studies of high-dose metoclopramide with and without forced diuresis

  • Ch. Ell
  • J. Braun
  • H. J. König
  • S. Domschke
  • W. Domschke
Wissenschaftliche Kurzmitteilungen
  • 14 Downloads

Summary

The pharmacokinetics of high-dose metoclopramide (10 mg/kg body wt. in five infusions of 2 mg/kg body wt. each) was studied in 11 patients (5 females, 6 males) in two groups: group A with and group B (consisting of five patients) without forced diuresis. When the drug was infused, forced diuresis had no influence on the pharmacokinetics of metoclopramide (serum level after the 1st infusion was 851±361 ng/ml in group A versus 840±348 ng/ml in group B; after the 5th infusion it was 2,005±588 ng/ml in group A versus 2,463±1,350 ng/ml in group B). There were significant differences in the 24-h serum levels (582±308 ng/ml in group A versus 379±170 ng/ml in group B;P<0.05) and in the elimination half life (8.5±2.6 h in group A versus 6.1±1.1 h in group B;P<0.05). The results demonstrate that the dosage regimen originally suggested by Gralla for cytostatic drugs, with forced diuresis for high-dose metoclopramide therapy, may also be applied, with no dosage reduction, with to other cytostatic drugs which do not require forced diuresis.

Key words

Metoclopramide High dose Metoclopramide Pharmacokinetics Antiemetics 

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References

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Copyright information

© Springer-Verlag GmbH & Co. KG 1985

Authors and Affiliations

  • Ch. Ell
    • 1
  • J. Braun
    • 2
  • H. J. König
    • 1
  • S. Domschke
    • 1
  • W. Domschke
    • 1
  1. 1.Medizinische Universitätsklinik Erlangen-NürnbergGermany
  2. 2.4. Medizinische KlinikInstitut für NephrologieNürnberg

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