Summary
Fructose-lysine, which is formed by binding glucose to lysine, is changed by acid hydrolysis into furosine.
Furosine derived from fructose-lysine of hair was determined by high-performance liquid chromatography according to the method of Schleicher et al.
Furosine values were significantly higher in diabetic patients than in healthy subjects, and significantly correlated with the stable components of hemoglobin A1 (HbA1) values.
These results suggest that furosine, like HbA1, may become an indicator of past blood glucose control at any time in diabetic patients and be useful in investigating diabetic complications on the level of tissue.
Abbreviations
- HbA1 :
-
Hemoglobin A1
- HPLC:
-
High-performance liquid chromatography
- TBA:
-
Thiobarbituric acid
References
Gabbay KH, Hasty K, Breslow JL, Ellison C, Bunn HF, Gallop PM (1977) Glycosylated hemoglobin and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab 44:859–864
Maillard MLC (1912) Action des acides aminés sur les sures: formation des méthodique. C R Acad Sci 72:599–601
Stevens VJ, Ronzer CA, Monnier VM, Cerami A (1978) Diabetic cataract formation: potential role of glycosylation and lens crystallins. Proc Natl Acad Sci 75:2918–2922
Rosenberg H, Madrak JB, Hassing JM, Al-Turk WA, Strohs SJ (1979) Glycosylated collagen. Biochem Biophys Res Commun 91:498–501
Cohen MP, Urdanivia E, Surma M, Wu V (1980) Increased glycosylation of glomerular basement membrane collagen in diabetics. Biochem Biophys Res Commun 95:765–769
Witztum JL, Mahoney EM, Branks MJ, Fisher M, Elam R, Steinberg D (1982) Nonenzymatic glucosylation of lowdensity lipoprotein alters its biologic activity. Diabetes 31:283–291
Amaya -F J, Lee T-C, Chichester CO (1976) Biological inactivation of proteins by the Maillard reaction. Effect of mild heat on the tertiary structure of insulin. J Agric Food Chem 24:465–467
Brüggemenn J, Erbersdobler H (1968) Fructoselysin als wichtigstes Reaktionsprodukt von Lysin mit Glucose bei Hitzebehandlung von Lebens- und Futtermitteln. Z Lebensm Unters Forsch 137:137–143
Oimomi M, Hatanaka H, Ishikawa K, Kubota S, Yoshimura Y, Baba S (1984) Increased fructose-lysine of nail protein in diabetic patients. Klin Wochenschr 62:477–478
Nathan DM (1981) A rapid chemical means for removing labile glycohemoglobin. Diabets 30:700–701
Schleicher E, Wieland OH (1981) Specific quantitation by HPLC of protein (lysine) bound glucose in human serum albumin and other glycosylated proteins. J Clin Chem Clin Biochem 19:81–87
Brownlee M, Vlassara H, Cerami A (1984) Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med 101:527–537
Griffiths WAD, Reshad H (1983) Hair and nail growth: an investigation of the role of left- and right-handedness. Clin Exp Dermatol 8:129–133
Flückiger R, Winterhalter KH (1976) In vitro synthesis of hemoglobin A1c. FEBS Lett 71:356–360
Oimomi M, Kawasaki T, Kubota S, Yoshimura Y, Baba S, Kato H (1984) Aspects of colorimetric method using thiobarbituric acid for the determination of glycosylated hemoglobin. Acta Hematol Jpn 47:868–872
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Oimomi, M., Nishimoto, S., Kitamura, Y. et al. Increased fructose-lysine of hair protein in diabetic patients. Klin Wochenschr 63, 728–730 (1985). https://doi.org/10.1007/BF01733118
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01733118