Klinische Wochenschrift

, Volume 63, Issue 15, pp 728–730 | Cite as

Increased fructose-lysine of hair protein in diabetic patients

  • M. Oimomi
  • S. Nishimoto
  • Y. Kitamura
  • S. Matsumoto
  • H. Hatanaka
  • K. Ishikawa
  • S. Baba
Wissenschaftliche Kurzmitteilungen


Fructose-lysine, which is formed by binding glucose to lysine, is changed by acid hydrolysis into furosine.

Furosine derived from fructose-lysine of hair was determined by high-performance liquid chromatography according to the method of Schleicher et al.

Furosine values were significantly higher in diabetic patients than in healthy subjects, and significantly correlated with the stable components of hemoglobin A1 (HbA1) values.

These results suggest that furosine, like HbA1, may become an indicator of past blood glucose control at any time in diabetic patients and be useful in investigating diabetic complications on the level of tissue.

Key words

Fructose-lysine Furosine Haemoglobin A1 Glycosylation Diabetes mellitus Hair 



Hemoglobin A1


High-performance liquid chromatography


Thiobarbituric acid


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. Oimomi
    • 1
  • S. Nishimoto
    • 1
  • Y. Kitamura
    • 1
  • S. Matsumoto
    • 1
  • H. Hatanaka
    • 1
  • K. Ishikawa
    • 1
  • S. Baba
    • 1
  1. 1.The Second Department of Internal MedicineKobe University School of MedicineKobeJapan

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