Effects of nicotine and its major metabolites on blood pressure in anaesthetized rats
- 62 Downloads
Blood pressure and heart rate in anaesthetized rats has been determined after i.v. injection of increasing doses of nicotine (NI) and its major metabolites, i.e. continine (CO), nornicotine (NOR), metanicotine (MN) and dihydrometanicotine (DMN). NI and MN elicited similar dose response curves, increasing blood pressure according to the dose injected. However, the dose response curve of MN was shifted to the right. Furthermore DMN caused similar pressor effects than MN and the pressor effects of NOR was even weaker. Only after injection of CO was a dose-dependent depressor effect observed and this was reversed after very high doses. CO also reduced heart rate in a dose-dependent manner, whereas NI and its other metabolites did not significantly change heart rate.
Key wordsNicotine and metabolites Dose-response curves Blood pressure Heart rate Anaesthetized rats
standard error of the mean
Unable to display preview. Download preview PDF.
- 1.Borzelleca JF, Bowman ER, McKennis H Jr (1962) Studies on the respiratory and cardiovascular effect of (-)-cotinine. J Pharmacol Exp Ther 137:313–318Google Scholar
- 2.Clark MSG, Rand MJ, Vanov S (1965) Comparison of pharmacological activity of nicotine and related alkaloids occurring in smoke. Arch Int Pharmacodyn Ther 156:363–379Google Scholar
- 3.Cryer PE, Haymond MW, Santiago JV, Shah SD (1976) Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med 295:(11) 573–577Google Scholar
- 4.Dominiak P, Kees F, Grobecker H (1984) Changes in Peripheral and Central Catecholaminergic and Serotoninergic Neurons of Rats After Acute and Subacute Administration of Nicotine. Klin Wochenschr 62 (Suppl II):76–80Google Scholar
- 5.Henrich H, Hessenauer A, Brune H (1984) Microcirculatory Effects of Nicotine and Related Alkaloids. Klin Wochenschr 62 (Suppl II):92–100Google Scholar
- 6.Kim KS, Borzelleca JF, Bowman ER, McKennis H Jr (1968) Effects of Some Nicotine Metabolites and Related Compounds on Isolated Smooth Muscle. J Pharmacol Exp Ther 161(1):59–69Google Scholar
- 7.Mattila MJ, Ahtee L, Vartiainen A (1965) Some central and peripheral effects of nor-nicotine derivates. In: v. Euler US (ed) Tobacco alkaloids and related compounds. Pergamon Press, Oxford, pp 321–330Google Scholar
- 8.Russel MAH, Raw M, Jarvis MJ (1980) Clinical use of nicotine chewing-gum. Br Med J 280:1590–1602Google Scholar
- 9.Werle E, Uschold E (1948) Überfermentative Nikotinvergiftung durch tierisches Gewebe. Biochem Z 318:531–537Google Scholar