Summary
Using a grouping method we studied the disease homogeneity within a group of 109 patients with systemic lupus erythematosus. The mean observation period was 6 years and 8 months. By using a cluster analysis, the total group of patients could be subdivided into two subgroups which differed clearly in their symptomatology. One subgroup (n=42) showed higher incidence of elevated serum creatinine values, proteinuria, oral ulceration and severe anaemia. All 13 deaths occurred in this group. The second group (n=67) was characterized by a more benign course of disease, a notably decreased incidence of renal involvement, and the Raynaud's Phenomenon was comparatively frequent.
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Bokemeyer, B., Thiele, K.G. Cluster-Analyse bei 109 Patienten mit systemischem Lupus erythematodes. Klin Wochenschr 63, 79–83 (1985). https://doi.org/10.1007/BF01733072
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DOI: https://doi.org/10.1007/BF01733072