Summary
Thromboembolic complications may occur in inflammatory bowel disease. Recently, we had the opportunity to observe a case of a cerebral arterial thrombosis in a young patient with active ulcerative colitis. Investigation of blood coagulation revealed a temporary Protein C, Protein S and Factor II deficiency. To our knowledge, this is the first reported case of a temporary Protein C and S deficiency in a patient with thrombosis and inflammatory bowel disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amical J, Adam I, Plassart V, Minard S, Vissac AM (1988) Immunoassays for the measurement of protein S. In: Gaffney PJ, Castellino FJ, Plow EF, Takada Y (eds) New aspects in fibrinolysis. Libbey, London, pp 125–128
Bougherty JH Jr, Levy DE, Weksler BB (1977) Platelet activation in acute cerebral ischemia: serial measurements of platelet function in cerebrovascular disease. Lancet I: 821–823
Dusser A, Boyer-Nuemann C, Wolf M (1988) Temporary protein C deficiency associated with cerebral arterial thrombosis in childhood. J Pediatr 113: 849–851
Edwards FC, Truelove SC (1964) The course and prognosis of ulcerative colitis. III. Complications. Gut 5: 1–22
Griffin JH, Mosher DF, Zimmerman TS, Kleiss AJ (1982) Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation. Blood 60: 261–264
Heeb MJ, Griffin JH (1988) Physiologic inhibition of human activated protein C by α1-antitrypsin. J Biol Chem 263: 11613–11616
Israels SJ, Seshia SS (1987) Childhood stroke associated with protein C and S deficiency. J Pediatr 111: 562–564
Knot E, Ten Cate JW, Leeksma OC, Tytgat GN, Vreeken J (1983) No evidence for a prethrombotic state in stable chronic inflammatory bowel disease. J Clin Pathol 36: 1387–1390
Krasinski SD, Russell RM, Furie BC, Kruger SF, Jacques PF, Furie B (1985) The prevalence of vitamin K deficiency in chronic gastrointestinal disorders. Am J Clin Nutr 41: 639–643
Lake AM, Stauffer JQ, Stuart MJ (1978) Hemostatic alterations in inflammatory bowel disease. Dig Dis 23: 897–902
Lee JCL, Spittell JA, Sauer WG, Owen CA, Thompson JH (1968) Hypercoagulability associated with chronic ulcerative colitis: changes in blood coagulation factors. Gastroenterology 54: 76–85
Mayeux R, Fahn S (1978) Strokes and ulcerative colitis. Neurology (Minneapolis Mn) 28: 571–574
Mori K, Watanabe H, Hiwatashi N, Sugai K, Goto Y (1980) Studies on blood coagulation in ulcerative colitis and Crohn's disease. Tohoku J Exp Med 132: 93–101
Odegaard OR, Tey K, Andersson RT (1987) Protein C: an automated activity assay. Haemostasis 17: 109–113
Rosenberg RD (1987) Regulation of hemostatic mechanism. In: Stamatoyannopaulos G, Nienhuis AW, Leder P, Majerus PW (eds) The molecular basis of blood diseases. WB Saunders, Philadelphia, pp 534–574
Schneiderman JH, Sharpe JA, Sutton DMC (1979) Cerebral and retinal vascular complications of inflammatory bowel disease. Ann Neurol 5: 331–337
Shafer AI (1985) The hypercoagulable states. Ann Intern Med 102: 814–828
Silverstein A, Present DH (1971) Cerebrovascular occlusions in relatively young patients with regional enteritis. JAMA 215: 976–979
Talbot RW, Heppell J, Dozois RR, Beart RW (1986) Vascular complications of inflammatory bowel disease. Mayo Clin Proc 61: 140–145
Vigano S, Mannucci PM, Solinas S, Botasso B, Mariani G (1984) Decrease in protein C antigen and formation of an abnormal protein soon after starting oral anticoagulant therapy. Br J Haematol 57: 2213–2220
Wyshock E, Caldwell M, Crowley JP (1988) Deep venous thrombosis, inflammatory bowel disease, and protein S deficiency. Am J Clin Pathol 90: 633–635
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jorens, P.G., Hermans, C.R., Haber, I. et al. Acquired protein C and S deficiency, inflammatory bowel disease and cerebral arterial thrombosis. Blut 61, 307–310 (1990). https://doi.org/10.1007/BF01732883
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01732883