Inadequacy of prebiotic synthesis as origin of proteinous amino acids

Summary

The production of some nonproteinous, and lack of production of other proteinous, amino acids in model prebiotic synthesis, along with the instability of glutamine and asparagine, suggest that not all of the 20 presentday proteinous amino acids gained entry into proteins directly from the primordial soup. Instead, a process of active co-evolution of the genetic code and its constituent amino acids would have to precede the final selection of these proteinous amino acids.

This is a preview of subscription content, access via your institution.

References

  1. Abelson, P.H. (1957). Ann. N.Y. Acad. Sci.69, 276–285

    Google Scholar 

  2. Allen, C.W. (1963). Astrophysical Quantities, 2nd edition. London: Athlone Press, p. 109

    Google Scholar 

  3. Barak, I., Bar-Nun, A. (1975). Origins of Life6, 483–506

    Google Scholar 

  4. Bruton, C.J., Hartley, B.S. (1968). Biochem. J.108, 281–288

    Google Scholar 

  5. Cassio, D., Waller, J.P. (1968). Eur. J. Biochem.5, 33–41

    Google Scholar 

  6. Dawson, R.M.C., Elliott, D.C., Elliott, W.H., Jones, K.M. (1969). Data for Biochemical Research, 2nd edition. Oxford, P. 485

  7. Fowden, L., Lewis, D., Tristram, H. (1967). Adv. Enzymol.29, 89–163

    Google Scholar 

  8. Grossenbacher, K.A., Knight, C.A. (1965). In: The Origins of Prebiological Systems, (Fox, S.W. ed.) New York: Academic Press, p. 173–183

    Google Scholar 

  9. Haldane, J.B.S. (1929). In: The Rationalist Annual, reprinted in Bernal J.D., The Origin of Life (1967). London: Weidenfeld and Nicolson, p. 242–249

    Google Scholar 

  10. Harada, K. (1967). Nature214, 479–480

    Google Scholar 

  11. Harada, K., Fox, S.W. (1964). Nature201, 335–336

    Google Scholar 

  12. Hong, K.Y., Hong, J.H., Becker, R.S. (1974). Science184, 984–987

    Google Scholar 

  13. Jukes, T.H. (1971). In: Prebiotic and Biochemical Evolution, (A.P. Kimball and J. Oro, eds.) North Holland/Elsevier, pp. 122–147

  14. Kvenvolden, K.A. (1974). In: The Origin of Life and Evolutionary Biochemistry, C.K. Dose, S.W. Fox, G.A. Deborin, T.E. Pavlovskaya, eds.) New York: Plenum, p. 301–309

    Google Scholar 

  15. Lawless, J.G., Boynton, C.D., (1973). Nature243, 405–407

    Google Scholar 

  16. Lawless, J.G., Kvenvolden, K.A., Peterson, E., Ponnamperuma, C., Moore, C. (1971). Science173, 626–627

    Google Scholar 

  17. Lowe, C.U., Rees, M.W., Markham, R. (1963). Nature199, 219–222

    Google Scholar 

  18. Marcker, K., Sanger, F. (1964). J. Mol. Biol.8, 835–840

    Google Scholar 

  19. Miller, S.L. (1953). Science117, 528–529

    Google Scholar 

  20. Miller, S.L., Orgel, L.E. (1974). The Origins of Life on the Earth. Englewood Cliffs, New Jersey: Prentice-Hall, p. 95

    Google Scholar 

  21. Miller, S.L., Urey, H.C., Oro, J.J. (1976). J. Mol. Evol.9, 59–72

    Google Scholar 

  22. Oparin, A.I. (1924). In: Proiskhozhdenie Zhizny, translated in Bernal, J.D. The Origin of Life (1967) London: Weidenfeld and Nicolson, pp. 199–234

    Google Scholar 

  23. Oro, J., Kamat, S.S. (1961). Nature190, 442–443

    Google Scholar 

  24. Palm, C., Calvin, M. (1962). J. Am. Chem. Soc.84, 2115–2121

    Google Scholar 

  25. Ring, D., Wolman, Y., Friedmann, N., Miller, S.L. (1972). Proc. Natl. Acad. Sci., USA69, 765–768

    Google Scholar 

  26. Rohlfing, D.L., Saunders, M.A. (1978). J. Theoret. Biol.71, 487–504

    Google Scholar 

  27. Sagan, C., Khare, B.N. (1971). Science173, 417–420

    Google Scholar 

  28. Salemme, F.R., Miller, M.D., Jordan, S.R. (1977). Proc. Natl. Acad. Sci., USA74, 2820–2824

    Google Scholar 

  29. Sonneborn, T.M. (1965). In: Evolving Genes and Proteins (V. Bryson and H.J. Vogel, eds.) New York: Academic Press, pp. 377–397

    Google Scholar 

  30. Telegina, T.A., Pavlovskaya, T.E., Ladyzhenskaya, A.I. (1974). Zhurnal Evolyutsionnoi Biokhimii i Fiziologii10, 129–134

    Google Scholar 

  31. Vallentyne, J.R. (1965). In: The Origins of Prebiological Systems, (S.W. Fox, ed.) New York and London: Academic Press, pp. 105–120

    Google Scholar 

  32. Wilcox, M., Nirenberg, M. (1968). Proc. Natl. Acad. Sci., USA61, 229–236

    Google Scholar 

  33. Woese, C. (1965). Proc. Natl. Acad. Sci. USA54, 1546–1552

    Google Scholar 

  34. Wolman, Y., Haverland, W.J., Miller, S.L. (1972). Proc. Natl. Acad. Sci., USA69, 809–811

    Google Scholar 

  35. Wong, J.T. (1975). Proc. Natl. Acad. Sci., USA72, 1909–1912

    Google Scholar 

  36. Wong, J.T. (1976). Proc. Natl. Acad. Sci., USA73, 2336–2340

    Google Scholar 

  37. Wong, J.T., Mustard, M., Herbert, E. (1969). Biochim. Biophys. Acta174, 513–524

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wong, J.TF., Bronskill, P.M. Inadequacy of prebiotic synthesis as origin of proteinous amino acids. J Mol Evol 13, 115–125 (1979). https://doi.org/10.1007/BF01732867

Download citation

Keywords

  • Glutamine
  • Asparagine
  • Genetic Code
  • Proteinous Amino Acid
  • Final Selection