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Langzeitwirkung von Glucagon auf die Magensekretion

Prolonged effect of glucagon on gastric secretion

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Summary

18 male subjects were given 4×2 mg glucagon i.m. per day in cristalline form and 4×4 g of CaCO3 orally for 8 days. A quantitative gastric analysis was performed 12 hours after the last dose of the medication and compared with the results of a gastric analysis carried out at the beginning of the test.

Maximally stimulated H-concentration and H-secretion were significantly reduced by glucagon application. The role of glucagon as a potential therapeutic substance for the reduction of gastric secretion in man is discussed.

Zusammenfassung

18 männliche Probanden erhielten über 8 Tage täglich 4×2 mg kristallines Glucagon i.m. und 4×4 g CaCO3 oral verabreicht. Am Testbeginn und 12 Std nach der letzen Medikamentengabe wurde jeweils eine quantitative Magensekretionsanalyse durchgeführt. Die maximale stimulierte H-Konzentration und H-Sekretion war nach der 8-tägigen Glucagonapplikation signifikant niedriger als davor.

Die Rolle des Glucagons als potentielles Therapeuticum zur Reduktion der gastralen HCl-Sekretion beim Menschen wird diskutiert.

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Literatur

  1. Avioli, L. V., Birge, S. J., Scott, S., Shieber, W.: Role of the thyroid gland during glucagon induced hypocalcemia in the dog. Amer. J. Physiol.216, 939 (1969).

    Google Scholar 

  2. Barreras, R. F.: Acid secretion after calcium carbonate in patients with doudenal ulcer. New Engl. J. Med.282, 1402 (1970).

    Google Scholar 

  3. Brown, J. C., Magee, F. D.: Inhibitory action of cholecystokinin on acid secretion from Heidenhain pouches induced by endogenous gastrin. Gut8, 29 (1967).

    Google Scholar 

  4. Byrnes, D. J., Young, D., Chisholm, D. J., Lazarus, L.: Serum gastrin in patients with peptic ulceration. Brit. med. J.1970II, 626.

    Google Scholar 

  5. Clarke, S. D., Neill, D. N., Welbourn, L. B.: Effect of glucagon on gastric secretion in the dog. Gut1, 146 (1960).

    Google Scholar 

  6. Cohen, N., Mazure, P., Dreiling, D. A., Janowitz, H. D.: Effect of glucagon on histamine-stimulated gastric secretion in man. Fed. Proc.18, 28 (1959).

    Google Scholar 

  7. Deyhle, P., Nitzsche, R., Miederer, S. E., Ottenjann, R.: Über die Wirkung von Glukagon auf die Magensekretion. 76. Tagg Dtsch. Ges. Inn. Med., April 1970.

  8. Dotevall, G., Kock, N. G., Walan, A.: Inhibition of pentagastrin-induced gastric acid secretion in man by glucagon given intravenously. Scand. J. Gastroent.4, 713 (1969).

    Google Scholar 

  9. Gillespie, I. E., Grossman, M. I.: Inhibitory effect of secretin and cholecystokinin on Heidenhain pouch responses to gastrin extract and histamine. Gut5, 342 (1964).

    Google Scholar 

  10. Grossman, M. I.: Treatment of duodenal ulcer with secretin: a speculative proposal. Gastroenterology50, 912 (1966).

    Google Scholar 

  11. Kock, N. G., Darle, N., Dotevall, G.: Inhibition of intestinal motility in man by glucagon given intraportally. Gastroenterology53, 88 (1967).

    Google Scholar 

  12. La Barre, J., Castiau, J.: A propos des effects antiulcereaux de la secretine. 7th Congr. Intern. de l'Assoc. de Soc. Nat. Europ. et Meditérran. de Gastro-Entérologie, Bruxelles (1964), Abstr. p. 34.

  13. Lin, T. M., Alphin, R. S.: Inhibition of gastric secretion by glucagon and glucose in the dog. Fed. Proc.17, 97 (1958).

    Google Scholar 

  14. —— Spray, G. F.: Effect of glucagon on gastric HCl-secretion. Gastroenterology54, 1254 (1968)—Abstr.

    Google Scholar 

  15. Ottenjann, R., Dehhle, P., Paul, F.: Über den Einfluß von Glukagon auf die gastrale Sekretion bei synchroner Calciuminfusion. Klin. Wschr.47, 724 (1969).

    Google Scholar 

  16. —— Paul, F., Deyhle, P.: Über den Einfluß intravenöser Phosphatpufferinfusion auf Serumcalcium und Magensekretion. Klin. Wschr.47, 723 (1969).

    Google Scholar 

  17. Paloyan, E., Paloyan, D., Harper, R. V.: Glucagon-induced hypocalcemia. Metabolism16, 35 (1967).

    Google Scholar 

  18. Paul, F., Deyhle, P., Ottenjann, R.: Über den Effekt von oralem Calcium und Magnesium auf die HCl-Sekretion des Magens. Münch. med. Wschr.12, 422 (1971).

    Google Scholar 

  19. Robinson, R. M., Harris, K., Hlad, C. D., Eiseman, B.: Effect of glucagon on gastric secretion. Proc. Soc. exp. Biol. (N.Y.)96, 518 (1957).

    Google Scholar 

  20. Scratcherd, T., Case, R. M.: The role of cyclic adenosine-3′5′-monophosphate (AMP) in gastro-intestinal secretion. Gut10, 957 (1969).

    Google Scholar 

  21. Solomon, S. P., Spiro, H. M.: The effect of glucagon and glucose on the human stomach. Amer. J. dig. Dis.4, 775 (1959).

    Google Scholar 

  22. Trudeau, W. L., McGuigan, J. E.: Effect of calcium on serum gastrin levels in the Zollinger-Ellison syndrome. New Engl. J. Med.281, 862 (1969).

    Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik mit Poliklinik der Universität Erlangen-Nürnberg, Germany

    F. Paul & P. Deyhle

  2. Gastroent. Abteilung, Dept. Innere Medizin der Medizinischen Hochschule Hannover, Podbielskistr. 380, D-3000, Hannover, Deutschland

    F. Paul

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  1. F. Paul
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  2. P. Deyhle
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Paul, F., Deyhle, P. Langzeitwirkung von Glucagon auf die Magensekretion. Klin Wochenschr 49, 1229–1231 (1971). https://doi.org/10.1007/BF01732732

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  • DOI: https://doi.org/10.1007/BF01732732

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