Journal of Molecular Evolution

, Volume 15, Issue 2, pp 129–148 | Cite as

Sequence homologies amongE. coli ribosomal proteins: Evidence for evolutionarily related groupings and internal duplications

  • R. A. Jue
  • N. W. Woodbury
  • R. F. Doolittle


The complete or partial sequences of 47E. coli ribosomal proteins described in the literature have been examined by computerized search and matching programs. In contrast to results previously reported by other investigators, sequence homologies were uncovered among some of these ribosomal proteins that are well beyond statistical expectations. Moreover, alignments of the most strongly homologous sequences suggested the existence of a network of family groupings. Several of these proteins also exhibit internal homologies, indicating that they have been elongated by a series of tandem duplications.

Key words

Ribosomal proteins Gene duplications Homologous sequences Protein evolution Computer sequence matching 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barker, W.C., Dayhoff, M.O. (1972) 'Detecting distant relationships; computer methods and results. In: Atlas of protein sequence and structure Vol.5, pp. 101–110. Washington: National Biomedical Research FoundationGoogle Scholar
  2. Brownlee, G.G., Sanger, F., Barren, B.G. (1967). Nature215, 735–736Google Scholar
  3. Chen, R., Giorginis, S. (1977). FEBS Lett.84, 347–350Google Scholar
  4. Dognin, M.J., Wittmann-Liebold, B. (1977). FEBS Lett.84, 342–346Google Scholar
  5. Dzionara, M., Robinson, S.M.L., Wittmann-Liebold, B. (1977). J. Supramolecular Structure70, 191–204Google Scholar
  6. Finkelstein, A.V. (1977). FEBS Lett.82 169–171Google Scholar
  7. Fitch, W.M. (1966). J. Mol. Biol.16, 9–16Google Scholar
  8. Fitch, W.M. (1970). Syst. Zool.19, 99–113Google Scholar
  9. Funatsu, G., Yaguchi, M., Wittmann-Liebold, B. (1977). FEBS Lett.73, 12–17Google Scholar
  10. Hitz, H., Schafer, D., Wittmann-Liebold, B. (1975). FEBS Lett.56, 259–262Google Scholar
  11. Lindemann, H., Wittmann-Liebold, B. (1976). FEBS Lett.71, 251–255Google Scholar
  12. Metzger, H., Shapiro, M.P., Mosimann, J.E., Vinton, J.E. (1968). Nature219, 1166–1168Google Scholar
  13. Morinaga, T., Funatsu, G., Funatsu, M., Wittmann-Liebold, B., Wittmann, H.G. (1978). FEBS Lett.91, 74–77Google Scholar
  14. Needleman, S.B., Wunsch, C.D. (1970). J. Mol. Biol.48, 443–453Google Scholar
  15. Stöffler, G., Wittmann, H.G. (1977). Proteins within theEscbericbia coli ribosome In: Molecular mechanisms in protein biosynthesis, H. Weissbach, S. Pestka, eds., p. 117. New York: AcademicGoogle Scholar
  16. Wittmann-Liebold, B. (1973). FEBS Lett.36, 247–249Google Scholar
  17. Wittmann-Liebold, B., Geissler, A.W., Marzinig, E. (1975). J. Supramolecular Structure.3, 426–447Google Scholar
  18. Wittmann-Liebold, B., Dzionara, M. (1976a). FEBS Lett.61, 14–19Google Scholar
  19. Wittmann-Liebold, B., Dzionara, M. (1976b). FEBS Lett.65, 281–283Google Scholar
  20. Wittmann-Liebold, B., Robinson, S.M.L., Dzionara, M. (1977). FEBS Lett.81, 204–213Google Scholar
  21. Woodward, D.R. (1978). J. Theo. Biol.72, 743–749Google Scholar
  22. Yaguchi, M., Wittmann, H.G. (1978a). FEBS Lett.87, 37–40Google Scholar
  23. Yaguchi, M., Wittmann, H.G. (1978b). FEBS Lett.88, 227–230Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • R. A. Jue
    • 1
  • N. W. Woodbury
    • 1
  • R. F. Doolittle
    • 1
  1. 1.Department of ChemistryUniversity of CaliforniaSan Diego, La JollaUSA

Personalised recommendations