Journal of Molecular Evolution

, Volume 15, Issue 2, pp 103–112 | Cite as

Nucleotide-amino acid interactions and their relation to the genetic code

  • Jacques Reuben
  • Freddie E. Polk


The apparent dissociation constants of the complexes of AMP with the methyl esters of amino acids in aqueous solution exhibit good correlations with features of the genetic code and with the frequencies of occurrence of amino acid residues in proteins. Thus it is likely that chemically selective nucleotide-amino acid interactions were involved in the processes of chemical evolution that have led to the emergence of the genetic code. Based on these correlations a storage device for the information regarding nucleotide-amino acid interactions is proposed. It involves processes of simultaneous polymerization to polynucleotides and polypeptides.

Key words

Hydrophobic interactions NMR spectroscopy 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Jacques Reuben
    • 1
  • Freddie E. Polk
    • 1
  1. 1.Department of ChemistryUniversity of HoustonHoustonUSA

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